Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.35 |
| ▸ | TSHR | P16473 | 3/20 | 0.35 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 4/20 | 0.34 |
| ▸ | MAPT | P10636 | 7/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.33 |
| ▸ | GAA | P10253 | 4/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | GFER | P55789 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | GRK6 | P43250 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 3/20 | 0.33 |
| ▸ | USP2 | O75604 | 2/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.33 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8946686 | 1.00 | ALDH1A1 (0.35) | ALDH1A1TSHRCREBBPLMNAMAPT | |
| SCHEMBL8946696 | 1.00 | ALDH1A1 (0.35) | ALDH1A1TSHRCREBBPLMNAMAPT | |
| SCHEMBL8946786 | 0.85 | CREBBP (0.40) | ALDH1A1TSHRCREBBPLMNAMAPT | |
| SCHEMBL8946705 | 0.76 | HSD17B3 (0.39) | ALDH1A1CREBBPMAPTKMT2AGAA | |
| SCHEMBL8946692 | 0.76 | HSD17B3 (0.39) | ALDH1A1CREBBPMAPTKMT2AGAA | |
| SCHEMBL8946666 | 0.72 | MAPT (0.49) | ALDH1A1LMNAMAPTGAAHIF1A | |
| SCHEMBL8946337 | 0.68 | AVPR2 (0.33) | ALDH1A1TSHRLMNAMAPTKMT2A | |
| SCHEMBL8946326 | 0.68 | AVPR2 (0.33) | ALDH1A1TSHRLMNAMAPTKMT2A | |
| SCHEMBL8946434 | 0.63 | HSD17B3 (0.44) | ALDH1A1CREBBPLMNAMAPTL3MBTL1 | |
| SCHEMBL9094480 | 0.63 | LMNA (0.66) | ALDH1A1TSHRLMNAMAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5516788-A | TREATMENT OF ATHEROSCLEROSIS; ANTIISCHEMIC, ANTICARCINOGENIC AGENTS; ANTICOAGULANTS | UNIVERSITY OF BATH (GB) | 1996-05-14 | — | — | US | disclosed |
| EP-0409410-B1 | Indenoindole compounds | UNIV BATH (GB) | 1996-03-20 | — | — | EP | disclosed |
| EP-0409410-A1 | Indenoindole compounds | UNIVERSITY OF BATH (GB) | 1991-01-23 | — | — | EP | disclosed |
| WO-1990015799-A1 | INDENOINDOLE COMPOUNDS II | UNIVERSITY OF BATH (GB) | 1990-12-27 | — | — | WO | disclosed |