Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 11/20 | 1.00 |
| ▸ | MTNR1B | P49286 | 10/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.65 |
| ▸ | MEN1 | O00255 | 3/20 | 0.61 |
| ▸ | MAPT | P10636 | 3/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.61 |
| ▸ | HTT | P42858 | 1/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21075898 | 0.96 | MTNR1A (0.92) | MTNR1AMTNR1BALDH1A1MEN1MAPT | |
| SCHEMBL8946919 | 0.88 | MTNR1A (0.78) | MTNR1AMTNR1BALDH1A1KDM4ECYP1A2 | |
| SCHEMBL8946906 | 0.88 | MTNR1A (1.00) | MTNR1AMTNR1BALDH1A1KDM4ECYP1A2 | |
| SCHEMBL8947176 | 0.86 | MTNR1B (1.00) | MTNR1AMTNR1BALDH1A1KDM4ECYP1A2 | |
| SCHEMBL15428091 | 0.85 | MTNR1A (0.74) | MTNR1AMTNR1BALDH1A1KDM4ECYP1A2 | |
| SCHEMBL18222560 | 0.85 | MTNR1A (0.78) | MTNR1AMTNR1BALDH1A1MEN1MAPT | |
| SCHEMBL31543713 | 0.85 | MTNR1A (1.00) | MTNR1AMTNR1BALDH1A1MEN1MAPT | |
| SCHEMBL8946916 | 0.85 | MTNR1A (1.00) | MTNR1AMTNR1BALDH1A1MEN1MAPT | |
| SCHEMBL8946963 | 0.84 | MTNR1A (1.00) | MTNR1AMTNR1BALDH1A1KDM4ECYP1A2 | |
| SCHEMBL18239837 | 0.83 | MTNR1A (0.78) | MTNR1AMTNR1BALDH1A1MEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5552428-A | ANTIARRHYTHMIA AGENTS FOR CARDIOVASCULAR DISORDERS USING MELATONIN DERIVATIVES | INSTITUTO FARMACOLOGICO LOMBARDO-IFLO, S.A.S. (IT) | 1996-09-03 | — | — | US | disclosed |