Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.38 |
| ▸ | FEN1 | P39748 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8947317 | 0.90 | ALDH1A1 (0.57) | ALDH1A1HPGDTRPV1HSD11B1HDAC6 | |
| SCHEMBL8947152 | 0.88 | ALDH1A1 (0.50) | ALDH1A1HPGDTRPV1HSD11B1HDAC6 | |
| SCHEMBL8947240 | 0.86 | ALDH1A1 (0.54) | ALDH1A1HPGDTRPV1HSD11B1HDAC6 | |
| SCHEMBL8947310 | 0.84 | TRPV1 (0.63) | ALDH1A1HPGDTRPV1HSD11B1HDAC6 | |
| SCHEMBL8947149 | 0.84 | ALDH1A1 (0.51) | ALDH1A1HPGDTRPV1HSD11B1HDAC6 | |
| SCHEMBL8947140 | 0.84 | HSD11B1 (0.59) | ALDH1A1HPGDTRPV1HSD11B1TSHR | |
| SCHEMBL8947311 | 0.84 | ALDH1A1 (0.57) | ALDH1A1HPGDTRPV1HSD11B1HDAC6 | |
| SCHEMBL8947278 | 0.84 | ALDH1A1 (0.70) | ALDH1A1HPGDTRPV1HSD11B1CYP1A2 | |
| SCHEMBL8947063 | 0.84 | ALDH1A1 (0.46) | ALDH1A1HPGDTRPV1HSD11B1 | |
| SCHEMBL5966689 | 0.83 | TRPV1 (0.59) | ALDH1A1HPGDTRPV1HSD11B1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE35281-E | ANTIDIABETIC AGENTS | WAKAMOTO PHARMACEUTICAL CO., LTD. (JP) | 1996-06-18 | — | — | US | disclosed |
| EP-0388967-B1 | Aldose reductase inhibitor | WAKAMOTO PHARMA CO LTD (JP) | 1995-06-28 | — | — | EP | disclosed |
| US-5055481-A | Alleviate diabetic complications | WAKAMOTO PHARMACEUTICAL CO., LTD. (JP) | 1991-10-08 | — | — | US | disclosed |
| EP-0388967-A1 | Aldose reductase inhibitor | Wakamoto Pharmaceutical Co., Ltd. (JP) | 1990-09-26 | — | — | EP | disclosed |