Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.45 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8947288 | 0.95 | — | — | |
| SCHEMBL8947152 | 0.87 | ALDH1A1 (0.50) | ALDH1A1HPGDHSD11B1TRPV1 | |
| SCHEMBL8947317 | 0.87 | ALDH1A1 (0.57) | ALDH1A1HPGDHSD11B1TRPV1 | |
| SCHEMBL9568720 | 0.86 | MAPK1 (0.43) | ALDH1A1HPGDHSD11B1 | |
| SCHEMBL8947316 | 0.86 | ALDH1A1 (0.63) | ALDH1A1HPGDHSD11B1 | |
| SCHEMBL8947125 | 0.85 | L3MBTL1 (0.48) | ALDH1A1HPGDHSD11B1TRPV1 | |
| SCHEMBL8947169 | 0.84 | ALDH1A1 (0.49) | ALDH1A1HPGDHSD11B1TRPV1 | |
| SCHEMBL8947240 | 0.83 | ALDH1A1 (0.54) | ALDH1A1HPGDHSD11B1TRPV1 | |
| SCHEMBL8947078 | 0.81 | ALDH1A1 (0.60) | ALDH1A1HPGDHSD11B1 | |
| SCHEMBL8947140 | 0.81 | HSD11B1 (0.59) | ALDH1A1HPGDHSD11B1TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE35281-E | ANTIDIABETIC AGENTS | WAKAMOTO PHARMACEUTICAL CO., LTD. (JP) | 1996-06-18 | — | — | US | disclosed |
| EP-0388967-B1 | Aldose reductase inhibitor | WAKAMOTO PHARMA CO LTD (JP) | 1995-06-28 | — | — | EP | disclosed |
| US-5055481-A | Alleviate diabetic complications | WAKAMOTO PHARMACEUTICAL CO., LTD. (JP) | 1991-10-08 | — | — | US | disclosed |
| EP-0388967-A1 | Aldose reductase inhibitor | Wakamoto Pharmaceutical Co., Ltd. (JP) | 1990-09-26 | — | — | EP | disclosed |