Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.66 |
| ▸ | HPGD | P15428 | 1/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.51 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.51 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.51 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | MITF | O75030 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.43 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.42 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8947331 | 0.87 | ALDH1A1 (0.84) | ALDH1A1HPGDHTTLMNAHSD11B1 | |
| SCHEMBL8947081 | 0.84 | ALDH1A1 (0.47) | ALDH1A1HPGDSMN1; SMN2PKMSLC6A2 | |
| SCHEMBL8947307 | 0.84 | ALDH1A1 (0.53) | ALDH1A1HPGDSMN1; SMN2PKMHTT | |
| SCHEMBL8947334 | 0.82 | ALDH1A1 (0.56) | ALDH1A1HPGDSMN1; SMN2HTTMAPT | |
| SCHEMBL8947261 | 0.81 | ALDH1A1 (0.75) | ALDH1A1HPGDHTTKDM4EHSD11B1 | |
| SCHEMBL5966727 | 0.81 | ALDH1A1 (0.75) | ALDH1A1HPGDPTGS2HTTMAPT | |
| SCHEMBL8947281 | 0.81 | ALDH1A1 (0.75) | ALDH1A1HPGDHTTHSD11B1AKR1B1 | |
| SCHEMBL5966693 | 0.81 | ALDH1A1 (0.74) | ALDH1A1HPGDHTTKDM4EHSD11B1 | |
| SCHEMBL8947113 | 0.80 | ALDH1A1 (0.54) | ALDH1A1HPGDMAPTLMNAKMT2A | |
| SCHEMBL8947199 | 0.80 | ALDH1A1 (0.73) | ALDH1A1HPGDHTTHSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE35281-E | ANTIDIABETIC AGENTS | WAKAMOTO PHARMACEUTICAL CO., LTD. (JP) | 1996-06-18 | — | — | US | disclosed |
| EP-0388967-B1 | Aldose reductase inhibitor | WAKAMOTO PHARMA CO LTD (JP) | 1995-06-28 | — | — | EP | disclosed |
| US-5055481-A | Alleviate diabetic complications | WAKAMOTO PHARMACEUTICAL CO., LTD. (JP) | 1991-10-08 | — | — | US | disclosed |
| EP-0388967-A1 | Aldose reductase inhibitor | Wakamoto Pharmaceutical Co., Ltd. (JP) | 1990-09-26 | — | — | EP | disclosed |