Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.45 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | VCAM1 | P19320 | 2/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.39 |
| ▸ | F2 | P00734 | 1/20 | 0.39 |
| ▸ | DHFR | P00374 | 1/20 | 0.39 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.38 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8947334 | 0.88 | ALDH1A1 (0.56) | ALDH1A1HPGDMAPTMEN1KMT2A | |
| SCHEMBL8947241 | 0.86 | LMNA (0.46) | ALDH1A1HPGDMAPTMEN1KMT2A | |
| SCHEMBL7414782 | 0.81 | MAPT (0.43) | ALDH1A1MAPTMEN1KMT2AL3MBTL1 | |
| SCHEMBL8947170 | 0.80 | ALDH1A1 (0.66) | ALDH1A1HPGDAKR1B1MAPTMEN1 | |
| SCHEMBL8947307 | 0.78 | ALDH1A1 (0.53) | ALDH1A1HPGDMAPTMEN1KMT2A | |
| SCHEMBL8947331 | 0.77 | ALDH1A1 (0.84) | ALDH1A1HPGDHSD11B1P2RX7LMNA | |
| SCHEMBL8947260 | 0.76 | ALDH1A1 (0.73) | ALDH1A1HPGDL3MBTL1HSD11B1P2RX7 | |
| SCHEMBL8947269 | 0.75 | TRPV1 (0.43) | ALDH1A1HPGDMAPTMEN1KMT2A | |
| SCHEMBL8947333 | 0.74 | ALDH1A1 (0.65) | ALDH1A1HPGDMAPTMEN1KMT2A | |
| SCHEMBL20338958 | 0.72 | S1PR1 (0.44) | ALDH1A1AKR1B10AKR1B1MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE35281-E | ANTIDIABETIC AGENTS | WAKAMOTO PHARMACEUTICAL CO., LTD. (JP) | 1996-06-18 | — | — | US | disclosed |
| EP-0388967-B1 | Aldose reductase inhibitor | WAKAMOTO PHARMA CO LTD (JP) | 1995-06-28 | — | — | EP | disclosed |
| US-5055481-A | Alleviate diabetic complications | WAKAMOTO PHARMACEUTICAL CO., LTD. (JP) | 1991-10-08 | — | — | US | disclosed |
| EP-0388967-A1 | Aldose reductase inhibitor | Wakamoto Pharmaceutical Co., Ltd. (JP) | 1990-09-26 | — | — | EP | disclosed |