Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | GRK6 | P43250 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | CES2 | O00748 | 1/20 | 0.42 |
| ▸ | CES1 | P23141 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 6/20 | 0.40 |
| ▸ | LMNA | P02545 | 4/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | MITF | O75030 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8947113 | 0.88 | ALDH1A1 (0.54) | ALDH1A1HPGDCYP1A2MEN1KMT2A | |
| SCHEMBL8947269 | 0.87 | TRPV1 (0.43) | ALDH1A1HPGDGRK6TSHRCYP1A2 | |
| SCHEMBL8947333 | 0.84 | ALDH1A1 (0.65) | ALDH1A1HPGDTSHRCYP1A2POLB | |
| SCHEMBL8947170 | 0.82 | ALDH1A1 (0.66) | ALDH1A1HPGDMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL8947307 | 0.80 | ALDH1A1 (0.53) | ALDH1A1HPGDMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL8947331 | 0.79 | ALDH1A1 (0.84) | ALDH1A1HPGDPOLBLMNAHTT | |
| SCHEMBL8947241 | 0.77 | LMNA (0.46) | ALDH1A1HPGDMEN1KMT2AMAPT | |
| SCHEMBL5966727 | 0.77 | ALDH1A1 (0.75) | ALDH1A1HPGDPOLBRAB9AMAPT | |
| SCHEMBL8947275 | 0.76 | ALDH1A1 (0.61) | ALDH1A1HPGDCYP1A2POLBMEN1 | |
| SCHEMBL8947235 | 0.74 | ALDH1A1 (0.59) | ALDH1A1HPGDPOLBMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE35281-E | ANTIDIABETIC AGENTS | WAKAMOTO PHARMACEUTICAL CO., LTD. (JP) | 1996-06-18 | — | — | US | disclosed |
| EP-0388967-B1 | Aldose reductase inhibitor | WAKAMOTO PHARMA CO LTD (JP) | 1995-06-28 | — | — | EP | disclosed |
| US-5055481-A | Alleviate diabetic complications | WAKAMOTO PHARMACEUTICAL CO., LTD. (JP) | 1991-10-08 | — | — | US | disclosed |
| EP-0388967-A1 | Aldose reductase inhibitor | Wakamoto Pharmaceutical Co., Ltd. (JP) | 1990-09-26 | — | — | EP | disclosed |