Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RECQL | P46063 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.54 |
| ▸ | HPGD | P15428 | 3/20 | 0.54 |
| ▸ | RAB9A | P51151 | 4/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | TSHR | P16473 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 4/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.50 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8947295 | 0.89 | TSHR (0.61) | RECQLALDH1A1HPGDRAB9AMAPT | |
| SCHEMBL8947275 | 0.85 | ALDH1A1 (0.61) | RECQLALDH1A1HPGDMAPTHSD11B1 | |
| SCHEMBL5966725 | 0.84 | ALDH1A1 (0.68) | ALDH1A1HPGDRAB9ATSHRLMNA | |
| SCHEMBL8947235 | 0.81 | ALDH1A1 (0.59) | ALDH1A1HPGDMAPTLMNANPC1 | |
| SCHEMBL5966693 | 0.80 | ALDH1A1 (0.74) | ALDH1A1HPGDTSHRHSD11B1KDM4C | |
| SCHEMBL8947300 | 0.80 | ALDH1A1 (0.70) | ALDH1A1HPGDSMN1; SMN2HSD11B1KDM4C | |
| SCHEMBL28781397 | 0.79 | ALDH1A1 (0.53) | RECQLALDH1A1HPGDMAPTLMNA | |
| SCHEMBL8947261 | 0.78 | ALDH1A1 (0.75) | ALDH1A1HPGDHSD11B1KDM4CKDM4E | |
| SCHEMBL9469451 | 0.77 | ALDH1A1 (0.62) | ALDH1A1HPGDLMNAHSD11B1KDM4C | |
| SCHEMBL8947299 | 0.77 | ALDH1A1 (0.66) | ALDH1A1HPGDHSD11B1KDM4CPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE35281-E | ANTIDIABETIC AGENTS | WAKAMOTO PHARMACEUTICAL CO., LTD. (JP) | 1996-06-18 | — | — | US | disclosed |
| EP-0388967-B1 | Aldose reductase inhibitor | WAKAMOTO PHARMA CO LTD (JP) | 1995-06-28 | — | — | EP | disclosed |
| US-5055481-A | Alleviate diabetic complications | WAKAMOTO PHARMACEUTICAL CO., LTD. (JP) | 1991-10-08 | — | — | US | disclosed |
| EP-0388967-A1 | Aldose reductase inhibitor | Wakamoto Pharmaceutical Co., Ltd. (JP) | 1990-09-26 | — | — | EP | disclosed |