Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.59 |
| ▸ | HPGD | P15428 | 3/20 | 0.59 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.48 |
| ▸ | PDE4A | P27815 | 1/20 | 0.47 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8947266 | 0.88 | ALDH1A1 (0.48) | ALDH1A1HPGDNPC1POLBSMN1; SMN2 | |
| SCHEMBL8947137 | 0.85 | ALDH1A1 (0.53) | ALDH1A1HPGDSMN1; SMN2HSD11B1MAPT | |
| SCHEMBL5966725 | 0.82 | ALDH1A1 (0.68) | ALDH1A1HPGDNPC1SMN1; SMN2HSD11B1 | |
| SCHEMBL8947141 | 0.82 | ALDH1A1 (0.53) | ALDH1A1HPGDPDE4BLMNA | |
| SCHEMBL8947331 | 0.81 | ALDH1A1 (0.84) | ALDH1A1HPGDPOLBHSD11B1LMNA | |
| SCHEMBL8947333 | 0.81 | ALDH1A1 (0.65) | ALDH1A1HPGDNPC1POLBSMN1; SMN2 | |
| SCHEMBL8947238 | 0.81 | RECQL (0.60) | ALDH1A1HPGDNPC1POLBSMN1; SMN2 | |
| SCHEMBL5966727 | 0.79 | ALDH1A1 (0.75) | ALDH1A1HPGDNPC1POLBHSD11B1 | |
| SCHEMBL8947275 | 0.78 | ALDH1A1 (0.61) | ALDH1A1HPGDPOLBHSD11B1MAPT | |
| SCHEMBL8947261 | 0.76 | ALDH1A1 (0.75) | ALDH1A1HPGDPOLBHSD11B1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE35281-E | ANTIDIABETIC AGENTS | WAKAMOTO PHARMACEUTICAL CO., LTD. (JP) | 1996-06-18 | — | — | US | disclosed |
| EP-0388967-B1 | Aldose reductase inhibitor | WAKAMOTO PHARMA CO LTD (JP) | 1995-06-28 | — | — | EP | disclosed |
| US-5055481-A | Alleviate diabetic complications | WAKAMOTO PHARMACEUTICAL CO., LTD. (JP) | 1991-10-08 | — | — | US | disclosed |
| EP-0388967-A1 | Aldose reductase inhibitor | Wakamoto Pharmaceutical Co., Ltd. (JP) | 1990-09-26 | — | — | EP | disclosed |