Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.62 |
| ▸ | HPGD | P15428 | 1/20 | 0.62 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.49 |
| ▸ | HSD11B1 | P28845 | 5/20 | 0.46 |
| ▸ | RPA1 | P27694 | 1/20 | 0.42 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8947261 | 0.84 | ALDH1A1 (0.75) | ALDH1A1HPGDKDM4CHSD11B1KDM4E | |
| SCHEMBL5966693 | 0.84 | ALDH1A1 (0.74) | ALDH1A1HPGDKDM4CHSD11B1KDM4E | |
| SCHEMBL8947331 | 0.83 | ALDH1A1 (0.84) | ALDH1A1HPGDKDM4CHSD11B1LMNA | |
| SCHEMBL9568758 | 0.81 | ALDH1A1 (0.41) | ALDH1A1HPGDHSD11B1KDM4ELMNA | |
| SCHEMBL8947299 | 0.81 | ALDH1A1 (0.66) | ALDH1A1HPGDKDM4CHSD11B1HDAC6 | |
| SCHEMBL8947275 | 0.80 | ALDH1A1 (0.61) | ALDH1A1HPGDKDM4CHSD11B1KDM4E | |
| SCHEMBL8947333 | 0.80 | ALDH1A1 (0.65) | ALDH1A1HPGDKDM4CHSD11B1LMNA | |
| SCHEMBL9568773 | 0.79 | ALDH1A1 (0.56) | ALDH1A1HPGDKDM4CHSD11B1HDAC6 | |
| SCHEMBL5966727 | 0.78 | ALDH1A1 (0.75) | ALDH1A1HPGDKDM4CHSD11B1KDM4E | |
| SCHEMBL8947281 | 0.78 | ALDH1A1 (0.75) | ALDH1A1HPGDKDM4CHSD11B1AKR1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5262433-A | Antidiabetic agents | WAKAMOTO PHARMACEUTICAL CO., LTD. (JP) | 1993-11-16 | — | — | US | disclosed |
| US-5252592-A | Tetrazoleacetic acid derivatives having aldose reductase inhibitory activity | WAKAMOTO PHARMACEUTICAL CO., LTD. (JP) | 1993-10-12 | — | — | US | disclosed |
| EP-0528277-A1 | Tetrazoleacetic acid derivatives aldose reductase inhibitors | Wakamoto Pharmaceutical Co., Ltd. (JP) | 1993-02-24 | — | — | EP | disclosed |