Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.48 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.47 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8947336 | 0.88 | TRPV1 (0.56) | TRPV1HSD11B1MAPTKCNN4CYP1A2 | |
| SCHEMBL8947264 | 0.86 | P2RX7 (0.49) | TRPV1HSD11B1P2RX7MAPTTP53 | |
| SCHEMBL8947245 | 0.84 | ALDH1A1 (0.55) | HSD11B1P2RX7MAPTTP53ALDH1A1 | |
| SCHEMBL5966689 | 0.83 | TRPV1 (0.59) | TRPV1HSD11B1MAPTCYP1A2GAA | |
| SCHEMBL8947317 | 0.81 | ALDH1A1 (0.57) | TRPV1HSD11B1CYP1A2GAACYP2C19 | |
| SCHEMBL8947310 | 0.81 | TRPV1 (0.63) | TRPV1HSD11B1MAPTCYP1A2GAA | |
| SCHEMBL8947240 | 0.77 | ALDH1A1 (0.54) | TRPV1HSD11B1CYP1A2GAACYP2C19 | |
| SCHEMBL8947122 | 0.77 | ALDH1A1 (0.47) | TRPV1HSD11B1MAPTTP53CYP1A2 | |
| SCHEMBL8947277 | 0.77 | TRPV1 (0.50) | TRPV1HSD11B1CYP1A2GAACYP2C19 | |
| SCHEMBL8947215 | 0.76 | MGLL (0.56) | TRPV1HSD11B1CYP1A2GAACYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE35281-E | ANTIDIABETIC AGENTS | WAKAMOTO PHARMACEUTICAL CO., LTD. (JP) | 1996-06-18 | — | — | US | disclosed |
| EP-0388967-B1 | Aldose reductase inhibitor | WAKAMOTO PHARMA CO LTD (JP) | 1995-06-28 | — | — | EP | disclosed |
| US-5055481-A | Alleviate diabetic complications | WAKAMOTO PHARMACEUTICAL CO., LTD. (JP) | 1991-10-08 | — | — | US | disclosed |
| EP-0388967-A1 | Aldose reductase inhibitor | Wakamoto Pharmaceutical Co., Ltd. (JP) | 1990-09-26 | — | — | EP | disclosed |