Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 7/20 | 0.49 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.46 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.43 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8947250 | 0.86 | TRPV1 (0.48) | P2RX7TRPV1HSD11B1MAPTTP53 | |
| SCHEMBL8947336 | 0.85 | TRPV1 (0.56) | TRPV1HSD11B1MAPTKDM4EALDH1A1 | |
| SCHEMBL9170587 | 0.83 | P2RX7 (0.55) | P2RX7DOT1LHSD11B1NPC1ALDH1A1 | |
| SCHEMBL5966689 | 0.81 | TRPV1 (0.59) | TRPV1HSD11B1MAPTKDM4EALDH1A1 | |
| SCHEMBL8947340 | 0.79 | BCL2 (0.45) | KDM4EALDH1A1 | |
| SCHEMBL8947317 | 0.79 | ALDH1A1 (0.57) | TRPV1HSD11B1KDM4EALDH1A1HPGD | |
| SCHEMBL8947311 | 0.78 | ALDH1A1 (0.57) | TRPV1HSD11B1MAPTKDM4EALDH1A1 | |
| SCHEMBL8947310 | 0.78 | TRPV1 (0.63) | TRPV1HSD11B1MAPTKDM4EALDH1A1 | |
| SCHEMBL8947126 | 0.76 | P2RX7 (0.47) | P2RX7MAPTTP53KDM4ENPC1 | |
| SCHEMBL8947240 | 0.75 | ALDH1A1 (0.54) | TRPV1HSD11B1KDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE35281-E | ANTIDIABETIC AGENTS | WAKAMOTO PHARMACEUTICAL CO., LTD. (JP) | 1996-06-18 | — | — | US | disclosed |
| EP-0388967-B1 | Aldose reductase inhibitor | WAKAMOTO PHARMA CO LTD (JP) | 1995-06-28 | — | — | EP | disclosed |
| US-5055481-A | Alleviate diabetic complications | WAKAMOTO PHARMACEUTICAL CO., LTD. (JP) | 1991-10-08 | — | — | US | disclosed |
| EP-0388967-A1 | Aldose reductase inhibitor | Wakamoto Pharmaceutical Co., Ltd. (JP) | 1990-09-26 | — | — | EP | disclosed |