Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.61 |
| ▸ | HPGD | P15428 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 4/20 | 0.41 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8947275 | 0.86 | ALDH1A1 (0.61) | ALDH1A1HPGDCYP1A2HSD11B1KDM4C | |
| SCHEMBL5966727 | 0.84 | ALDH1A1 (0.75) | ALDH1A1HPGDHSD11B1KDM4CRAB9A | |
| SCHEMBL8947195 | 0.83 | TRPV1 (0.44) | ALDH1A1HPGDLMNACYP1A2HSD11B1 | |
| SCHEMBL8947331 | 0.83 | ALDH1A1 (0.84) | ALDH1A1HPGDLMNAHSD11B1KDM4C | |
| SCHEMBL8947333 | 0.80 | ALDH1A1 (0.65) | ALDH1A1HPGDLMNACYP1A2HSD11B1 | |
| SCHEMBL5966693 | 0.80 | ALDH1A1 (0.74) | ALDH1A1HPGDHSD11B1KDM4CHDAC6 | |
| SCHEMBL8947341 | 0.80 | ALDH1A1 (0.53) | ALDH1A1HPGDLMNACYP1A2SMN1; SMN2 | |
| SCHEMBL8947137 | 0.80 | ALDH1A1 (0.53) | ALDH1A1HPGDLMNAHSD11B1KDM4C | |
| SCHEMBL8947199 | 0.79 | ALDH1A1 (0.73) | ALDH1A1HPGDHSD11B1KDM4CHDAC6 | |
| SCHEMBL8947261 | 0.77 | ALDH1A1 (0.75) | ALDH1A1HPGDHSD11B1KDM4CHDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE35281-E | ANTIDIABETIC AGENTS | WAKAMOTO PHARMACEUTICAL CO., LTD. (JP) | 1996-06-18 | — | — | US | disclosed |
| EP-0388967-B1 | Aldose reductase inhibitor | WAKAMOTO PHARMA CO LTD (JP) | 1995-06-28 | — | — | EP | disclosed |
| US-5055481-A | Alleviate diabetic complications | WAKAMOTO PHARMACEUTICAL CO., LTD. (JP) | 1991-10-08 | — | — | US | disclosed |
| EP-0388967-A1 | Aldose reductase inhibitor | Wakamoto Pharmaceutical Co., Ltd. (JP) | 1990-09-26 | — | — | EP | disclosed |