Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.65 |
| ▸ | HPGD | P15428 | 1/20 | 0.65 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 4/20 | 0.42 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8947331 | 0.86 | ALDH1A1 (0.84) | ALDH1A1HPGDPOLBHSD11B1KDM4C | |
| SCHEMBL8947122 | 0.85 | ALDH1A1 (0.47) | ALDH1A1HPGDPOLBPKMHSD11B1 | |
| SCHEMBL8947334 | 0.84 | ALDH1A1 (0.56) | ALDH1A1HPGDPOLBRECQLLMNA | |
| SCHEMBL5966727 | 0.83 | ALDH1A1 (0.75) | ALDH1A1HPGDPOLBHSD11B1KDM4C | |
| SCHEMBL8947275 | 0.82 | ALDH1A1 (0.61) | ALDH1A1HPGDPOLBHSD11B1KDM4C | |
| SCHEMBL8947235 | 0.81 | ALDH1A1 (0.59) | ALDH1A1HPGDPOLBPKMHSD11B1 | |
| SCHEMBL8947259 | 0.80 | ALDH1A1 (0.61) | ALDH1A1HPGDPOLBHSD11B1KDM4C | |
| SCHEMBL8947281 | 0.80 | ALDH1A1 (0.75) | ALDH1A1HPGDPOLBHSD11B1KDM4C | |
| SCHEMBL8947261 | 0.80 | ALDH1A1 (0.75) | ALDH1A1HPGDPOLBHSD11B1KDM4C | |
| SCHEMBL9469451 | 0.80 | ALDH1A1 (0.62) | ALDH1A1HPGDPOLBHSD11B1KDM4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE35281-E | ANTIDIABETIC AGENTS | WAKAMOTO PHARMACEUTICAL CO., LTD. (JP) | 1996-06-18 | — | — | US | disclosed |
| EP-0388967-B1 | Aldose reductase inhibitor | WAKAMOTO PHARMA CO LTD (JP) | 1995-06-28 | — | — | EP | disclosed |
| US-5055481-A | Alleviate diabetic complications | WAKAMOTO PHARMACEUTICAL CO., LTD. (JP) | 1991-10-08 | — | — | US | disclosed |
| EP-0388967-A1 | Aldose reductase inhibitor | Wakamoto Pharmaceutical Co., Ltd. (JP) | 1990-09-26 | — | — | EP | disclosed |