Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.48 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | CCR3 | P51677 | 5/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | PTPN11 | Q06124 | 2/20 | 0.40 |
| ▸ | CASR | P41180 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8947275 | 0.80 | ALDH1A1 (0.61) | ALDH1A1HPGDHSD11B1MEN1CYP1A2 | |
| SCHEMBL5966693 | 0.78 | ALDH1A1 (0.74) | ALDH1A1HPGDHSD11B1HDAC6KDM4C | |
| SCHEMBL8947300 | 0.78 | ALDH1A1 (0.70) | ALDH1A1HPGDHSD11B1MEN1CYP1A2 | |
| SCHEMBL8947261 | 0.76 | ALDH1A1 (0.75) | ALDH1A1HPGDHSD11B1HDAC6KDM4C | |
| SCHEMBL8947331 | 0.75 | ALDH1A1 (0.84) | ALDH1A1HPGDHSD11B1HDAC6KDM4C | |
| SCHEMBL8947238 | 0.75 | RECQL (0.60) | ALDH1A1HPGDHSD11B1NPC1RAB9A | |
| SCHEMBL8947354 | 0.75 | POLB (0.65) | ALDH1A1HPGDHSD11B1MEN1CYP1A2 | |
| SCHEMBL28781397 | 0.74 | ALDH1A1 (0.53) | ALDH1A1HPGDHSD11B1MEN1CYP1A2 | |
| SCHEMBL8947307 | 0.74 | ALDH1A1 (0.53) | ALDH1A1HPGDHSD11B1MEN1KMT2A | |
| SCHEMBL8947313 | 0.73 | MAPT (0.44) | HPGDMEN1CYP1A2CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE35281-E | ANTIDIABETIC AGENTS | WAKAMOTO PHARMACEUTICAL CO., LTD. (JP) | 1996-06-18 | — | — | US | disclosed |
| EP-0388967-B1 | Aldose reductase inhibitor | WAKAMOTO PHARMA CO LTD (JP) | 1995-06-28 | — | — | EP | disclosed |
| US-5055481-A | Alleviate diabetic complications | WAKAMOTO PHARMACEUTICAL CO., LTD. (JP) | 1991-10-08 | — | — | US | disclosed |
| EP-0388967-A1 | Aldose reductase inhibitor | Wakamoto Pharmaceutical Co., Ltd. (JP) | 1990-09-26 | — | — | EP | disclosed |