SCHEMBL8947580

SCHEMBL8947580

Cc1ccc(Nc2ccc(O)c3c2C(=O)c2ccccc2C3=O)c(C)c1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ P2RY4 P51582 3/20 0.57
▸ P2RY2 P41231 2/20 0.57
▸ RAB9A P51151 2/20 0.56
▸ MEN1 O00255 6/20 0.53
▸ KMT2A Q03164 6/20 0.53
▸ MAPT P10636 5/20 0.53
▸ MAOA P21397 1/20 0.53
▸ TDP1 Q9NUW8 4/20 0.51
▸ MAPK1 P28482 4/20 0.51
▸ NPSR1 Q6W5P4 2/20 0.51
▸ LMNA P02545 2/20 0.51
▸ NPC1 O15118 1/20 0.51
▸ L3MBTL1 Q9Y468 1/20 0.51
▸ HTT P42858 1/20 0.50
▸ MAP1LC3B Q9GZQ8 1/20 0.46
▸ PRKCA P17252 2/20 0.46
▸ ALDH1A1 P00352 1/20 0.46
▸ MET P08581 1/20 0.46
▸ POLB P06746 3/20 0.45
▸ PABPC1 P11940 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6055493 0.91 P2RY4 (0.64) P2RY4P2RY2RAB9AMEN1KMT2A
SCHEMBL10613738 0.90 RAPGEF4 (0.47) P2RY4P2RY2RAB9AMEN1KMT2A
SCHEMBL13346017 0.90 RAPGEF4 (0.47) P2RY4P2RY2RAB9AMEN1KMT2A
SCHEMBL13346033 0.88 MAPT (0.54) P2RY4P2RY2RAB9AMEN1KMT2A
SCHEMBL7082773 0.87 MAPT (0.58) P2RY4P2RY2RAB9AMEN1KMT2A
SCHEMBL16985236 0.86 MAPT (0.56) P2RY4P2RY2RAB9AMEN1KMT2A
SCHEMBL13345996 0.86 P2RY4 (0.59) P2RY4P2RY2RAB9AMEN1KMT2A
SCHEMBL27926525 0.85 MEN1 (0.49) P2RY4P2RY2RAB9AMEN1KMT2A
SCHEMBL11536975 0.85 MAOA (0.57) P2RY4P2RY2RAB9AMEN1KMT2A
SCHEMBL13316762 0.85 P2RY4 (0.59) P2RY4P2RY2RAB9AMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9839591-B2 Anionic dye or brightener bearing an ammonium or phosphonium counterion, dye composition comprising them and process for dyeing keratin fibres using these dyes L'OREAL (FR) 2017-12-12 — — US disclosed
US-9504637-B2 Coloring agents and methods of use thereof LIVING PROOF, INC. (US) 2016-11-29 — — US disclosed
US-20160106648-A1 COLORING AGENTS AND METHODS OF USE THEREOF LIVING PROOF, INC. (US) 2016-04-21 — — US disclosed
US-9248086-B2 Coloring agents and methods of use thereof LIVING PROOF, INC. (US) 2016-02-02 — — US disclosed
US-20150174026-A1 COLORING AGENTS AND METHODS OF USE THEREOF LIVING PROOF, INC. 2015-06-25 — — US disclosed
US-8932370-B2 Coloring agents and methods of use thereof LIVING PROOF, INC. (US) 2015-01-13 — — US disclosed
US-20140326269-A1 COLORING AGENTS AND METHODS OF USE THEREOF LIVING PROOF, INC. 2014-11-06 — — US disclosed
US-8758451-B2 Coloring agents and methods of use thereof LIVING PROOF, INC. (US) 2014-06-24 — — US disclosed
US-20140013520-A1 COLORING AGENTS AND METHODS OF USE THEREOF LIVING PROOF, INC. 2014-01-16 — — US disclosed
US-8444715-B2 Coloring agents and methods of use thereof LIVING PROOF, INC. (US) 2013-05-21 — — US disclosed
US-20120272990-A1 COLORING AGENTS AND METHODS OF USE THEREOF LIVING PROOF, INC. (US) 2012-11-01 — — US disclosed
US-8187340-B2 Coloring agents and methods of use thereof LIVING PROOF, INC. (US) 2012-05-29 — — US disclosed
US-20110154583-A1 COLORING AGENTS AND METHODS OF USE THEREOF LIVING PROOF, INC. (US) 2011-06-30 — — US disclosed
CN-101374495-A Colorant for keratin fibers PROCTER & GAMBLE (US) 2009-02-25 — — CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120272990-A1 COLORING AGENTS AND METHODS OF USE THEREOF MPO, HLA-C, ADH7 P2RY4 4422/4885P2RY2 4676/4885RAB9A 3476/4885
US-20110154583-A1 COLORING AGENTS AND METHODS OF USE THEREOF MPO, HLA-C, ADH7 P2RY4 4422/4885P2RY2 4676/4885RAB9A 3476/4885
US-20160106648-A1 COLORING AGENTS AND METHODS OF USE THEREOF MPO, HLA-C, ADH7 P2RY4 4422/4885P2RY2 4676/4885RAB9A 3476/4885
US-20140013520-A1 COLORING AGENTS AND METHODS OF USE THEREOF MPO, HLA-C, ADH7 P2RY4 4422/4885P2RY2 4676/4885RAB9A 3476/4885
US-20150174026-A1 COLORING AGENTS AND METHODS OF USE THEREOF MPO, HLA-C, ADH7 P2RY4 4422/4885P2RY2 4676/4885RAB9A 3476/4885
US-20140326269-A1 COLORING AGENTS AND METHODS OF USE THEREOF MPO, HLA-C, ADH7 P2RY4 4422/4885P2RY2 4676/4885RAB9A 3476/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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