Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 15/20 | 1.00 |
| ▸ | HTR2C | P28335 | 8/20 | 1.00 |
| ▸ | DRD2 | P14416 | 7/20 | 0.64 |
| ▸ | HTR2A | P28223 | 5/20 | 0.64 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.51 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.51 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8948002 | 0.93 | HTR1A (0.87) | HTR1AHTR2CDRD2HTR2A | |
| SCHEMBL8947912 | 0.92 | HTR1A (0.85) | HTR1AHTR2CDRD2HTR2A | |
| SCHEMBL8785477 | 0.88 | HTR1A (0.79) | HTR1AHTR2CDRD2HTR2AADRA1D | |
| SCHEMBL8948066 | 0.87 | HTR1A (0.77) | HTR1AHTR2CDRD2HTR2A | |
| SCHEMBL8785701 | 0.85 | HTR1A (1.00) | HTR1AHTR2CDRD2HTR2AADRA1A | |
| SCHEMBL8786139 | 0.84 | HTR1A (0.72) | HTR1AHTR2CDRD2HTR2AADRA1A | |
| SCHEMBL8948219 | 0.83 | HTR1A (0.70) | HTR1AHTR2CDRD2HTR2A | |
| SCHEMBL8786294 | 0.82 | HTR1A (1.00) | HTR1AHTR2CDRD2HTR2AADRA1D | |
| SCHEMBL4891426 | 0.82 | HTR1A (0.75) | HTR1AHTR2CDRD2HTR2AADRA1D | |
| SCHEMBL8109930 | 0.81 | HTR1A (0.69) | HTR1AHTR2CDRD2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5234924-A | Hypotensive agents | ADIR ET COMPAGNIE (FR) | 1993-08-10 | — | — | US | claimed |
| US-5534517-A | (Aryl(alkyl)carbonyl)-heterocyclic compounds and their use in the treatment of anxiety and depression | ADIR ET COMPAGNIE (FR) | 1996-07-09 | — | — | US | disclosed |
| US-5387586-A | Analgesics, nervous system disorders | ADIR ET COMPAGNIE (FR) | 1995-02-07 | — | — | US | disclosed |
| EP-0613898-A1 | Aryl or arylalkyl-carbonyl heterocyclic derivatives, processes for their preparation and compositions containing them | ADIR ET COMPAGNIE (FR) | 1994-09-07 | — | — | EP | disclosed |
| US-5234924-A | Hypotensive agents | ADIR ET COMPAGNIE (FR) | 1993-08-10 | — | — | US | disclosed |