Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 8/20 | 0.69 |
| ▸ | HTR2C | P28335 | 7/20 | 0.69 |
| ▸ | SIGMAR1 | Q99720 | 7/20 | 0.65 |
| ▸ | DRD2 | P14416 | 1/20 | 0.54 |
| ▸ | HTR2A | P28223 | 1/20 | 0.54 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8958326 | 0.92 | SIGMAR1 (0.67) | HTR1AHTR2CSIGMAR1MEN1TP53 | |
| SCHEMBL8116065 | 0.85 | HTR1A (0.67) | HTR1AHTR2CSIGMAR1DRD2HTR2A | |
| SCHEMBL8948209 | 0.81 | HTR1A (1.00) | HTR1AHTR2CDRD2HTR2A | |
| SCHEMBL8100829 | 0.79 | DRD2 (0.53) | HTR1ASIGMAR1DRD2HTR2ACHRNA7 | |
| SCHEMBL8100660 | 0.79 | SIGMAR1 (1.00) | HTR1AHTR2CSIGMAR1 | |
| SCHEMBL8110695 | 0.78 | SIGMAR1 (0.67) | HTR1AHTR2CSIGMAR1 | |
| SCHEMBL8948219 | 0.78 | HTR1A (0.70) | HTR1AHTR2CSIGMAR1DRD2HTR2A | |
| SCHEMBL8114274 | 0.78 | GRIN2B (0.60) | HTR1AHTR2CSIGMAR1DRD2HTR2A | |
| SCHEMBL8948027 | 0.76 | HTR1A (0.57) | HTR1AHTR2CSIGMAR1HTR2ACYP1A2 | |
| SCHEMBL8948002 | 0.75 | HTR1A (0.87) | HTR1AHTR2CSIGMAR1DRD2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0673933-B1 | Aminoalkyl benzoxazolinones and benzothiazolinones process for their preparation and compositions containing them | ADIR (FR) | 2000-11-08 | — | — | EP | disclosed |
| US-5534511-A | AFFINITY FOR SIGMA RECEPTORS, ANTIINFLAMMATORY, TREATMENT OF ARTHRITIS | ADIR ET COMPAGNIE (FR) | 1996-07-09 | — | — | US | disclosed |
| US-5534517-A | (Aryl(alkyl)carbonyl)-heterocyclic compounds and their use in the treatment of anxiety and depression | ADIR ET COMPAGNIE (FR) | 1996-07-09 | — | — | US | disclosed |
| EP-0673933-A1 | Aminoalkyl benzoxazolinones and benzothiazolinones process for their preparation and compositions containing them | ADIR ET COMPAGNIE (FR) | 1995-09-27 | — | — | EP | disclosed |
| US-5387586-A | Analgesics, nervous system disorders | ADIR ET COMPAGNIE (FR) | 1995-02-07 | — | — | US | disclosed |
| EP-0613898-A1 | Aryl or arylalkyl-carbonyl heterocyclic derivatives, processes for their preparation and compositions containing them | ADIR ET COMPAGNIE (FR) | 1994-09-07 | — | — | EP | disclosed |