Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.48 |
| ▸ | HRH1 | P35367 | 3/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.45 |
| ▸ | LTA4H | P09960 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.42 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.39 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.39 |
| ▸ | TERT | O14746 | 1/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8948173 | 0.99 | SIGMAR1 (0.46) | SIGMAR1HRH1SLC6A4SLC6A3DRD2 | |
| SCHEMBL7759833 | 0.88 | SIGMAR1 (0.51) | SIGMAR1HRH3CHRM2KCNH2 | |
| SCHEMBL8948349 | 0.87 | SLC6A4 (0.37) | SIGMAR1SLC6A4SLC6A3DRD2HRH3 | |
| SCHEMBL8100564 | 0.86 | SIGMAR1 (0.49) | SIGMAR1SLC6A4SLC6A3SLC6A2 | |
| SCHEMBL8869700 | 0.86 | SIGMAR1 (0.49) | SIGMAR1SLC6A4SLC6A3SLC6A2 | |
| SCHEMBL9449991 | 0.85 | SIGMAR1 (0.47) | SIGMAR1HRH1HRH3CHRM2KCNH2 | |
| SCHEMBL8958234 | 0.84 | SIGMAR1 (0.58) | SIGMAR1SLC6A4SLC6A3SLC6A2 | |
| SCHEMBL8116418 | 0.84 | SIGMAR1 (0.58) | SIGMAR1SLC6A4SLC6A3SLC6A2 | |
| SCHEMBL9449597 | 0.82 | SIGMAR1 (0.55) | SIGMAR1TMEM97 | |
| SCHEMBL9685609 | 0.82 | DRD2 (0.39) | SIGMAR1DRD2HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5512569-A | SIGMA RECEPTOR DISORDERS; PSYCHOLOGICAL DISORDERS | ADIR ET COMPAGNIE (FR) | 1996-04-30 | — | — | US | disclosed |