Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 2/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 8/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | CRHBP | P24387 | 1/20 | 0.35 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | EBP | Q15125 | 2/20 | 0.35 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8948173 | 0.88 | SIGMAR1 (0.46) | SLC6A4HRH3SIGMAR1DRD2SLC6A3 | |
| SCHEMBL8948263 | 0.87 | SIGMAR1 (0.48) | SLC6A4HRH3SIGMAR1TMEM97DRD2 | |
| SCHEMBL7759833 | 0.86 | SIGMAR1 (0.51) | HRH3SIGMAR1POLB | |
| SCHEMBL9449991 | 0.82 | SIGMAR1 (0.47) | HRH3SIGMAR1KDM1APOLBSMN1; SMN2 | |
| SCHEMBL9449597 | 0.80 | SIGMAR1 (0.55) | SIGMAR1EBPTMEM97KDM4E | |
| SCHEMBL9685609 | 0.80 | DRD2 (0.39) | SIGMAR1SMN1; SMN2DRD2 | |
| SCHEMBL7759855 | 0.79 | CCR3 (0.58) | SIGMAR1DRD2KDM4E | |
| SCHEMBL7760492 | 0.79 | — | — | |
| SCHEMBL9684037 | 0.79 | S1PR1 (0.38) | SLC6A4SIGMAR1DRD2SLC6A3KDM4E | |
| SCHEMBL9437752 | 0.78 | THRA (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5512569-A | SIGMA RECEPTOR DISORDERS; PSYCHOLOGICAL DISORDERS | ADIR ET COMPAGNIE (FR) | 1996-04-30 | — | — | US | disclosed |