Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 14/20 | 0.44 |
| ▸ | ITGB3 | P05106 | 4/20 | 0.42 |
| ▸ | ITGA2B | P08514 | 4/20 | 0.42 |
| ▸ | F10 | P00742 | 4/20 | 0.42 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.42 |
| ▸ | PRSS2 | P07478 | 3/20 | 0.42 |
| ▸ | PRSS3 | P35030 | 3/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8948804 | 0.89 | SIGMAR1 (0.46) | SIGMAR1ITGB3ITGA2BF10PRSS1 | |
| SCHEMBL8948623 | 0.88 | SIGMAR1 (0.48) | SIGMAR1ITGB3ITGA2BF10PRSS1 | |
| SCHEMBL8315274 | 0.87 | SIGMAR1 (0.43) | SIGMAR1ITGB3ITGA2BGPR119 | |
| SCHEMBL8313643 | 0.86 | F10 (0.49) | SIGMAR1ITGB3ITGA2BF10PRSS1 | |
| SCHEMBL8948671 | 0.84 | GRM2 (0.49) | SIGMAR1ITGB3ITGA2B | |
| SCHEMBL8948666 | 0.84 | GRM2 (0.49) | SIGMAR1ITGB3ITGA2B | |
| SCHEMBL8313647 | 0.82 | SIGMAR1 (0.46) | SIGMAR1ITGB3ITGA2B | |
| SCHEMBL8948496 | 0.82 | ITGB3 (0.47) | SIGMAR1ITGB3ITGA2BF10PRSS1 | |
| SCHEMBL27354608 | 0.78 | KDM4E (0.40) | SIGMAR1ITGB3ITGA2BF10PRSS1 | |
| SCHEMBL8948680 | 0.76 | F10 (0.58) | SIGMAR1ITGB3ITGA2BF10PRSS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1052231-C | Adhesion receptor antagonists | MERCK PATENT GMBH (DE) | 2000-05-10 | — | — | CN | disclosed |
| US-5532255-A | Adhesion receptor antagonists | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1996-07-02 | — | — | US | disclosed |
| CN-1097421-A | Adhesion receptor antagonists | MERCK PATENT GMBH (DE) | 1995-01-18 | — | — | CN | disclosed |