Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 13/20 | 0.46 |
| ▸ | ITGB3 | P05106 | 6/20 | 0.45 |
| ▸ | ITGA2B | P08514 | 6/20 | 0.45 |
| ▸ | PRSS1 | P07477 | 5/20 | 0.45 |
| ▸ | PRSS2 | P07478 | 5/20 | 0.45 |
| ▸ | PRSS3 | P35030 | 5/20 | 0.45 |
| ▸ | F10 | P00742 | 4/20 | 0.45 |
| ▸ | F2 | P00734 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8948623 | 0.91 | SIGMAR1 (0.48) | SIGMAR1ITGB3ITGA2BPRSS1PRSS2 | |
| SCHEMBL8948655 | 0.89 | SIGMAR1 (0.44) | SIGMAR1ITGB3ITGA2BPRSS1PRSS2 | |
| SCHEMBL8948704 | 0.87 | F10 (0.58) | SIGMAR1ITGB3ITGA2BPRSS1PRSS2 | |
| SCHEMBL8948680 | 0.87 | F10 (0.58) | SIGMAR1ITGB3ITGA2BPRSS1PRSS2 | |
| SCHEMBL8948785 | 0.87 | F10 (0.58) | SIGMAR1ITGB3ITGA2BPRSS1PRSS2 | |
| SCHEMBL8314726 | 0.87 | SIGMAR1 (0.44) | SIGMAR1ITGB3ITGA2B | |
| SCHEMBL8948671 | 0.86 | GRM2 (0.49) | SIGMAR1ITGB3ITGA2B | |
| SCHEMBL8948666 | 0.86 | GRM2 (0.49) | SIGMAR1ITGB3ITGA2B | |
| SCHEMBL8948693 | 0.85 | SIGMAR1 (0.43) | SIGMAR1ITGB3ITGA2B | |
| SCHEMBL8948496 | 0.85 | ITGB3 (0.47) | SIGMAR1ITGB3ITGA2BPRSS1PRSS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1052231-C | Adhesion receptor antagonists | MERCK PATENT GMBH (DE) | 2000-05-10 | — | — | CN | disclosed |
| US-5532255-A | Adhesion receptor antagonists | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1996-07-02 | — | — | US | disclosed |