Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 2/20 | 0.50 |
| ▸ | F10 | P00742 | 8/20 | 0.48 |
| ▸ | F2 | P00734 | 3/20 | 0.48 |
| ▸ | KDM2B | Q8NHM5 | 2/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
| ▸ | ITGB3 | P05106 | 4/20 | 0.40 |
| ▸ | ITGA2B | P08514 | 4/20 | 0.40 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.40 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.40 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.40 |
| ▸ | CCR5 | P51681 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8948618 | 0.89 | GRM2 (0.53) | GRM2F10F2SIGMAR1NOTUM | |
| SCHEMBL8311049 | 0.89 | GRM2 (0.53) | GRM2F10F2SIGMAR1NOTUM | |
| SCHEMBL8948494 | 0.89 | GRM2 (0.53) | GRM2F10F2SIGMAR1NOTUM | |
| SCHEMBL8948682 | 0.87 | F10 (0.52) | GRM2F10ITGB3ITGA2BPRSS1 | |
| SCHEMBL8948634 | 0.86 | GRM2 (0.47) | GRM2F10KDM2BSIGMAR1 | |
| SCHEMBL8948686 | 0.86 | L3MBTL1 (0.47) | GRM2F10SIGMAR1 | |
| SCHEMBL8453566 | 0.85 | GRM2 (0.48) | GRM2SIGMAR1 | |
| SCHEMBL8311318 | 0.84 | F10 (0.49) | GRM2F10F2SIGMAR1ITGB3 | |
| SCHEMBL8948681 | 0.84 | GRM2 (0.47) | GRM2SIGMAR1 | |
| SCHEMBL8948674 | 0.84 | GRM2 (0.46) | GRM2SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5532255-A | Adhesion receptor antagonists | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1996-07-02 | — | — | US | disclosed |
| EP-0623615-A1 | Adhesion-receptor antagonists | MERCK PATENT GmbH (DE) | 1994-11-09 | — | — | EP | disclosed |