Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Phosphoric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Diallyldisulfide SCHEMBL31552427 | 0.83 | TRPA1 (0.65) | TRPA1ALDH1A1CYP3A4HPGDALOX15 | |
| SCHEMBL11052262 | 0.68 | TRPA1 (0.52) | TRPA1ALDH1A1CYP3A4HPGDALOX15 | |
| SCHEMBL11052255 | 0.68 | — | — | |
| SCHEMBL3768646 | 0.67 | TRPA1 (0.40) | TRPA1ALDH1A1CYP3A4HPGDALOX15 | |
| Diallyldisulfide SCHEMBL27836895 | 0.67 | TRPA1 (0.65) | TRPA1ALDH1A1CYP3A4HPGDALOX15 | |
| Phosphoric Acid SCHEMBL9716420 | 0.67 | ALOX5 (0.48) | TRPA1ALDH1A1CYP3A4HPGDALOX15 | |
| SCHEMBL1993851 | 0.65 | — | — | |
| Phosphoric Acid SCHEMBL11625666 | 0.65 | TRPA1 (0.33) | TRPA1ALDH1A1CYP3A4HPGDALOX15 | |
| Diallyl Sulfide SCHEMBL27607774 | 0.65 | ALOX5 (0.52) | TRPA1ALDH1A1CYP3A4HPGDALOX15 | |
| Diallyldisulfide SCHEMBL18687005 | 0.64 | TRPA1 (1.00) | TRPA1ALDH1A1CYP3A4HPGDALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-8183985-A | — | — | None | — | — | JP | disclosed |
| JP-H08183985-A | LUBRICATING OIL COMPOSITION | TONEN CORP | 1996-07-16 | — | — | JP | disclosed |