Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP1 | P29466 | 4/20 | 0.54 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.41 |
| ▸ | KLK7 | P49862 | 1/20 | 0.41 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.41 |
| ▸ | IRAK4 | Q9NWZ3 | 4/20 | 0.40 |
| ▸ | KDM1A | O60341 | 2/20 | 0.40 |
| ▸ | CFTR | P13569 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8948991 | 1.00 | CASP1 (0.54) | CASP1CHEK1KLK7EGLN1IRAK4 | |
| SCHEMBL8949333 | 0.82 | HCRTR2 (0.41) | CHEK1EGLN1IRAK4CFTR | |
| SCHEMBL8949324 | 0.82 | HCRTR2 (0.41) | CHEK1EGLN1IRAK4CFTR | |
| SCHEMBL8949241 | 0.81 | NPC1 (0.45) | CHEK1EGLN1IRAK4CFTRRAB9A | |
| SCHEMBL8949251 | 0.81 | NPC1 (0.45) | CHEK1EGLN1IRAK4CFTRRAB9A | |
| SCHEMBL8949141 | 0.81 | EGLN1 (0.45) | CHEK1KLK7EGLN1IRAK4KDM1A | |
| SCHEMBL8949262 | 0.81 | EGLN1 (0.45) | CHEK1KLK7EGLN1IRAK4KDM1A | |
| SCHEMBL8949256 | 0.81 | EGLN1 (0.45) | CHEK1KLK7EGLN1IRAK4KDM1A | |
| SCHEMBL8409339 | 0.78 | NPC1 (0.61) | CHEK1EGLN1RAB9AMEN1KMT2A | |
| SCHEMBL8949327 | 0.77 | CNR2 (0.60) | KLK7RAB9AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5563268-A | FOR PREVENTING CELL AGGLOMERATION, TREATING THROMBOSIS, ARTERIOSCLEROSIS, BRAIN, LUNG OR CARDIOVASCULAR DISORDERS | DR. KARL THOMAE GMBH (DE) | 1996-10-08 | — | — | US | disclosed |
| US-5418233-A | FOR INHIBITING CELL AGGREGATION | KARL THOMAE GMBH (DE) | 1995-05-23 | — | — | US | disclosed |
| EP-0537696-A1 | Heterobiaryl derivatives, medicines containing those compounds and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1993-04-21 | — | — | EP | disclosed |