Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 1/20 | 0.43 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | CCNK | O75909 | 4/20 | 0.42 |
| ▸ | CDK12 | Q9NYV4 | 4/20 | 0.42 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.42 |
| ▸ | CDK2 | P24941 | 3/20 | 0.42 |
| ▸ | CCR6 | P51684 | 5/20 | 0.41 |
| ▸ | PDK1 | Q15118 | 2/20 | 0.40 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.40 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.40 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.40 |
| ▸ | NOS1 | P29475 | 1/20 | 0.40 |
| ▸ | NOS2 | P35228 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8949227 | 1.00 | PDGFRB (0.43) | PDGFRBPDGFRAKDM4ECCNKCDK12 | |
| SCHEMBL8949216 | 0.81 | PDGFRB (0.43) | PDGFRBPDGFRAPDK1PDK2PDK3 | |
| SCHEMBL8949224 | 0.81 | PDGFRB (0.43) | PDGFRBPDGFRAPDK1PDK2PDK3 | |
| SCHEMBL29817860 | 0.79 | ACHE (0.48) | PDGFRBPDGFRAPDK1HPGDRAB9A | |
| SCHEMBL8949132 | 0.79 | KCNH2 (0.43) | KDM4ECCNKCDK12CCNA2CDK2 | |
| SCHEMBL8948987 | 0.75 | CASP1 (0.54) | KDM4ERAB9ANPC1 | |
| SCHEMBL8948991 | 0.75 | CASP1 (0.54) | KDM4ERAB9ANPC1 | |
| SCHEMBL8949241 | 0.74 | NPC1 (0.45) | KDM4ERAB9ANPC1 | |
| SCHEMBL8949251 | 0.74 | NPC1 (0.45) | KDM4ERAB9ANPC1 | |
| SCHEMBL8409339 | 0.73 | NPC1 (0.61) | RAB9ASMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5563268-A | FOR PREVENTING CELL AGGLOMERATION, TREATING THROMBOSIS, ARTERIOSCLEROSIS, BRAIN, LUNG OR CARDIOVASCULAR DISORDERS | DR. KARL THOMAE GMBH (DE) | 1996-10-08 | — | — | US | disclosed |
| US-5418233-A | FOR INHIBITING CELL AGGREGATION | KARL THOMAE GMBH (DE) | 1995-05-23 | — | — | US | disclosed |
| EP-0537696-A1 | Heterobiaryl derivatives, medicines containing those compounds and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1993-04-21 | — | — | EP | disclosed |