Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 2/20 | 0.49 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.44 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.43 |
| ▸ | TNF | P01375 | 1/20 | 0.42 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.39 |
| ▸ | FAAH | O00519 | 2/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | MEP1A | Q16819 | 1/20 | 0.38 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.37 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.37 |
| ▸ | MMP12 | P39900 | 1/20 | 0.37 |
| ▸ | MMP13 | P45452 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | FBP1 | P09467 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6540746 | 0.85 | S1PR1 (0.45) | GSK3BGRM4ENPP2TNFS1PR1 | |
| SCHEMBL6481575 | 0.85 | S1PR1 (0.45) | GSK3BGRM4ENPP2TNFS1PR1 | |
| SCHEMBL4697927 | 0.85 | S1PR1 (0.45) | GSK3BGRM4ENPP2TNFS1PR1 | |
| SCHEMBL9646909 | 0.84 | LMNA (0.52) | GSK3BGRM4ENPP2TNFS1PR1 | |
| SCHEMBL27948985 | 0.81 | GSK3B (0.51) | GSK3BGRM4ENPP2TNFS1PR1 | |
| SCHEMBL25933186 | 0.81 | GLA (0.42) | GSK3BGRM4ENPP2TNFS1PR1 | |
| SCHEMBL12056784 | 0.81 | GRM4 (0.44) | GSK3BGRM4ENPP2TNFS1PR1 | |
| SCHEMBL11601220 | 0.80 | ENPP2 (0.48) | GSK3BGRM4ENPP2TNFS1PR1 | |
| SCHEMBL4693798 | 0.80 | ENPP2 (0.48) | GSK3BGRM4ENPP2TNFS1PR1 | |
| SCHEMBL25263668 | 0.80 | AOC3 (0.43) | GSK3BGRM4ENPP2TNFS1PR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5561142-A | Substituted sulfonamides as selective β3 agonists for the treatment of diabetes and obesity | MERCK & CO., INC. (US) | 1996-10-01 | — | — | US | disclosed |
| US-5541197-A | Substituted sulfonamides as selective β3 agonists for the treatment of diabetes and obesity | MERCK & CO., INC. (US) | 1996-07-30 | — | — | US | disclosed |