Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 5/20 | 0.53 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
| ▸ | APP | P05067 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | GCGR | P47871 | 7/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8878207 | 0.83 | HMGCR (0.55) | HMGCRADORA2AADORA1GCGR | |
| SCHEMBL8879043 | 0.81 | HMGCR (0.54) | HMGCRADORA2AADORA1APPKDM4E | |
| SCHEMBL8877873 | 0.80 | HMGCR (0.62) | HMGCRADORA2AADORA1APPGCGR | |
| SCHEMBL8876720 | 0.80 | HMGCR (0.59) | HMGCRADORA2AADORA1APPGCGR | |
| SCHEMBL8949830 | 0.78 | GCGR (0.45) | GCGR | |
| SCHEMBL8877180 | 0.75 | HMGCR (0.43) | HMGCRADORA2AADORA1APPKDM4E | |
| SCHEMBL9849239 | 0.75 | HMGCR (0.48) | HMGCRADORA2AADORA1APPKDM4E | |
| SCHEMBL9849223 | 0.73 | HMGCR (0.53) | HMGCRADORA2AADORA1KDM4ELMNA | |
| SCHEMBL8878478 | 0.73 | HMGCR (0.47) | HMGCRADORA2AADORA1APPKDM4E | |
| SCHEMBL8878480 | 0.73 | HMGCR (0.47) | HMGCRADORA2AADORA1APPKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5502057-A | Polysubstituted pyridines useful for treating lipoproteinanaemia and arteriosclerosis | BAYER AKTIENGESELLSCHAFT (DE) | 1996-03-26 | — | — | US | disclosed |
| US-5470982-A | Disubstituted pyridines | BAYER AKTIENGESELLSCHAFT (DE) | 1995-11-28 | — | — | US | disclosed |
| US-5173495-A | 7-[(2,6-dialkyl-4-furyl or thienyl-pyridyl)]-3,5-di-(dihydroxy-6-enoates) useful for treating circulatory diseases | BAYER AKTIENGESELLSCHAFT (DE) | 1992-12-22 | — | — | US | disclosed |
| US-4968689-A | Certain 2,6-diisopropyl-4-(4-fluoro-phenyl)-3,5-bis-dimethyl-3',5'-dihydroxy-hept-6-enoate-pyridine derivatives useful for treating lipoproteinaemia and arteriosclerosis | BAYER AKTIENGESELLSCHAFT (DE) | 1990-11-06 | — | — | US | disclosed |
| CN-1034716-A | Disubstituted pyridines and preparation method thereof | BAYER AG (DE) | 1989-08-16 | — | — | CN | disclosed |