SCHEMBL8950283

SCHEMBL8950283

Cc1ccc(C2C(=O)N3CCCCN3C2=O)c(C)c1

nearest known ligand 0.41

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 3/20 0.40
MEN1 O00255 3/20 0.39
KMT2A Q03164 3/20 0.39
ALDH1A1 P00352 2/20 0.39
HSD17B10 Q99714 2/20 0.39
HPGD P15428 2/20 0.39
ALOX15 P16050 1/20 0.39
ALOX12 P18054 1/20 0.39
BRCA1 P38398 1/20 0.39
FKBP1A P62942 1/20 0.38
NPC1 O15118 1/20 0.38
RAB9A P51151 1/20 0.38
MAPT P10636 1/20 0.37
MCOLN3 Q8TDD5 1/20 0.37
AADAT Q8N5Z0 2/20 0.35
LMNA P02545 1/20 0.35
NPSR1 Q6W5P4 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8950302 0.79 GAA (0.40) ALDH1A1MAPT
SCHEMBL16592343 0.78 FASN (0.32) ALDH1A1HSD17B10
Cga-271312 SCHEMBL6801995 0.77 HRH3 (0.37) SMN1; SMN2MEN1KMT2AALDH1A1HPGD
SCHEMBL16592329 0.76 FASN (0.33)
SCHEMBL8950304 0.75 KMT2A (0.44) MEN1KMT2AALDH1A1RAB9AMAPT
SCHEMBL10735338 0.74 ALDH1A1 (0.41) MEN1KMT2AALDH1A1HSD17B10HPGD
SCHEMBL10900447 0.73 HSD17B10 (0.44) MEN1KMT2AALDH1A1HSD17B10HPGD
SCHEMBL11215620 0.71 NOS3 (0.43) MEN1KMT2AALDH1A1HSD17B10HPGD
SCHEMBL11222146 0.71 MEN1 (0.40) SMN1; SMN2MEN1KMT2AALDH1A1HSD17B10
SCHEMBL14335649 0.71 DPP4 (0.34) SMN1; SMN2MEN1KMT2AALDH1A1HSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0577629-B1 NOVEL HERBICIDALLY, ACARICIDALLY AND INSECTICIDALLY ACTIVE COMPOUNDS CIBA GEIGY AG (CH) 1996-06-26 EP claimed
EP-0577629-A1 NOVEL HERBICIDALLY, ACARICIDALLY AND INSECTICIDALLY ACTIVE COMPOUNDS. CIBA GEIGY AG (CH) 1994-01-12 EP claimed
WO-1992016510-A1 NOVEL HERBICIDALLY, ACARICIDALLY AND INSECTICIDALLY ACTIVE COMPOUNDS CIBA-GEIGY AG (CH) 1992-10-01 WO claimed
EP-0577629-B1 NOVEL HERBICIDALLY, ACARICIDALLY AND INSECTICIDALLY ACTIVE COMPOUNDS CIBA GEIGY AG (CH) 1996-06-26 EP disclosed
US-5506193-A Herbicidally, acaricidally and insecticidally active pyrazolidine compounds CIBA-GEIGY CORPORATION (US) 1996-04-09 US disclosed
US-5494890-A FOR CONTROLLING WEEDS, INSECTS, MITES CIBA-GEIGY CORPORATION (US) 1996-02-27 US disclosed
EP-0577629-A1 NOVEL HERBICIDALLY, ACARICIDALLY AND INSECTICIDALLY ACTIVE COMPOUNDS. CIBA GEIGY AG (CH) 1994-01-12 EP disclosed
WO-1992016510-A1 NOVEL HERBICIDALLY, ACARICIDALLY AND INSECTICIDALLY ACTIVE COMPOUNDS CIBA-GEIGY AG (CH) 1992-10-01 WO disclosed