Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 5/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | ELANE | P08246 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.38 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.38 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9058447 | 0.78 | ALDH1A1 (0.45) | ALDH1A1HPGDHSD17B10ALOX15SMN1; SMN2 | |
| SCHEMBL8950076 | 0.77 | FEN1 (0.46) | ALDH1A1HPGDHSD17B10MAPTMAPK1 | |
| SCHEMBL8950426 | 0.74 | TSHR (0.39) | ALDH1A1HSD17B10ALOX15SMN1; SMN2MAPT | |
| SCHEMBL8950389 | 0.72 | PTGER4 (0.34) | ALDH1A1HPGDHSD17B10SMN1; SMN2MAPT | |
| SCHEMBL8950606 | 0.68 | CA2 (0.36) | ALDH1A1SMN1; SMN2MAPTRXFP1NPC1 | |
| SCHEMBL1248647 | 0.67 | SMN1; SMN2 (0.65) | ALDH1A1HSD17B10SMN1; SMN2MAPTMAPK1 | |
| SCHEMBL15005212 | 0.66 | ALDH1A1 (0.68) | ALDH1A1HPGDHSD17B10ALOX15SMN1; SMN2 | |
| SCHEMBL4958802 | 0.64 | ALDH1A1 (0.57) | ALDH1A1HPGDHSD17B10ALOX15SMN1; SMN2 | |
| SCHEMBL9058117 | 0.64 | FEN1 (0.47) | ALDH1A1HPGDHSD17B10MAPTMAPK1 | |
| SCHEMBL30007326 | 0.63 | NOTUM (0.71) | ALDH1A1HPGDHSD17B10ALOX15SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5538966-A | ENZYME INHIBITORS FOR TREATMENT OF GLAUCOMA | ALCON LABORATORIES, INC. (US) | 1996-07-23 | — | — | US | disclosed |