Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.62 |
| ▸ | LMNA | P02545 | 3/20 | 0.62 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | XBP1 | P17861 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SDHB | P21912 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | EDNRB | P24530 | 1/20 | 0.34 |
| ▸ | EDNRA | P25101 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8869963 | 0.89 | LMNA (0.50) | SMN1; SMN2LMNAMAPTALDH1A1NPC1 | |
| SCHEMBL9432390 | 0.89 | SMN1; SMN2 (0.50) | SMN1; SMN2LMNAMAPTALDH1A1NPC1 | |
| SCHEMBL9903409 | 0.85 | LMNA (0.58) | SMN1; SMN2LMNAMAPTALDH1A1NPC1 | |
| SCHEMBL9903210 | 0.83 | LMNA (0.56) | SMN1; SMN2LMNAMAPTALDH1A1NPC1 | |
| SCHEMBL38662046 | 0.82 | LMNA (0.60) | SMN1; SMN2LMNAMAPTALDH1A1NPC1 | |
| SCHEMBL9902724 | 0.82 | LMNA (0.55) | SMN1; SMN2LMNANPC1PTGS2RAB9A | |
| SCHEMBL9903430 | 0.80 | LMNA (0.53) | SMN1; SMN2LMNANPC1MAPK1RAB9A | |
| SCHEMBL2411422 | 0.79 | SMN1; SMN2 (0.43) | SMN1; SMN2LMNAMAPTALDH1A1NPC1 | |
| SCHEMBL1067726 | 0.77 | SMN1; SMN2 (1.00) | SMN1; SMN2LMNAMAPTALDH1A1HSD17B10 | |
| SCHEMBL8665287 | 0.76 | ALDH1A1 (0.50) | LMNAMAPTALDH1A1MAPK1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11629135-B2 | Pyrimidine derivatives as inhibitors of PD1/PD-L1 activation | JUBILANT PRODELL LLC (US) | 2023-04-18 | — | — | US | disclosed |
| US-20210179580-A1 | PYRIMIDINE DERIVATIVES AS INHIBITORS OF PD1/PD-L1 ACTIVATION | Jubilant Prodel LLC | 2021-06-17 | — | — | US | disclosed |
| US-20210179580-A1 | PYRIMIDINE DERIVATIVES AS INHIBITORS OF PD1/PD-L1 ACTIVATION | Jubilant Prodel LLC | 2021-06-17 | — | — | US | disclosed |
| EP-3707135-A1 | PYRIMIDINE DERIVATIVES AS INHIBITORS OF PD1/PD-L1 ACTIVATION | Jubilant Prodel LLC (US) | 2020-09-16 | — | — | EP | disclosed |
| CN-111386265-A | Pyrimidine derivatives as inhibitors of PD1/PD-L1 activation | 朱比连特普罗德尔有限责任公司 | 2020-07-07 | — | — | CN | disclosed |
| CN-105130908-B | The preparation method and its synthetic intermediate of the cyano methyl pyrimidine of 4,6 dialkoxy 2 | 组合化学工业株式会社 | 2018-03-27 | — | — | CN | disclosed |
| EP-2463277-B1 | METHOD FOR PRODUCING 4,6-DIALKOXY-2-CYANOMETHYLPYRIMIDINE AND SYNTHETIC INTERMEDIATE THEREOF | KUMIAI CHEMICAL INDUSTRY CO (JP) | 2017-11-08 | — | — | EP | disclosed |
| CN-105130908-A | Method for producing 4,6-dialkoxy-2-cyanomethylpyrimidine and synthetic intermediate thereof | IHARA CHEMICAL IND CO | 2015-12-09 | — | — | CN | disclosed |
| CN-102548972-B | Preparation method of 4, 6-dialkoxy-2-cyanomethylpyrimidine and synthetic intermediate thereof | IHARA CHEMICAL INDUSTRY CO.,LTD. (JP) | 2015-08-19 | — | — | CN | disclosed |
| US-8748605-B2 | Method for producing 4,6-dialkoxy-2-cyanomethylpyrimidine and synthetic intermediate thereof | IHARA CHEMICAL INDUSTRY CO., LTD. (JP) | 2014-06-10 | — | — | US | disclosed |
| US-20120190851-A1 | METHOD FOR PRODUCING 4,6-DIALKOXY-2-CYANOMETHYLPYRIMIDINE AND SYNTHETIC INTERMEDIATE THEREOF | IHARA CHEMICAL INDUSTRY CO., LTD. (JP) | 2012-07-26 | — | — | US | disclosed |
| CN-102548972-A | Preparation method of 4, 6-dialkoxy-2-cyanomethylpyrimidine and synthetic intermediate thereof | IHARA CHEMICAL IND CO | 2012-07-04 | — | — | CN | disclosed |
| EP-2463277-A1 | METHOD FOR PRODUCING 4,6-DIALKOXY-2-CYANOMETHYLPYRIMIDINE AND SYNTHETIC INTERMEDIATE THEREOF | Ihara Chemical Industry Co., Ltd. (JP) | 2012-06-13 | — | — | EP | disclosed |
| US-5506192-A | HERBICIDES | SANDOZ LTD. | 1996-04-09 | — | — | US | disclosed |
| US-5284820-A | Herbicidal substituted cycloalkenes | BAYER AKTIENGESELLSCHAFT (DE) | 1994-02-08 | — | — | US | disclosed |
| US-5262385-A | Pyrimidine ring containing | MITSUBISHI PETROCHEMICAL CO., LTD. (JP) | 1993-11-16 | — | — | US | disclosed |
| EP-0532948-A1 | Substituted cycloalkenes as herbicides | BAYER AG (DE) | 1993-03-24 | — | — | EP | disclosed |
| EP-0468766-A1 | Halogen-containing compounds, herbicidal composition containing the same as an active ingredient, and intermediary compounds therefor | Mitsubishi Chemical Corporation (JP) | 1992-01-29 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11629135-B2 | Pyrimidine derivatives as inhibitors of PD1/PD-L1 activation | PDCD1, CD274, PDCD1LG2 | SMN1; SMN2 1987/4885LMNA 1995/4885MAPT 253/4885 |
| US-20210179580-A1 | PYRIMIDINE DERIVATIVES AS INHIBITORS OF PD1/PD-L1 ACTIVATION | PDCD1, CD274, PDCD1LG2 | SMN1; SMN2 1987/4885LMNA 1995/4885MAPT 253/4885 |
| US-20120190851-A1 | METHOD FOR PRODUCING 4,6-DIALKOXY-2-CYANOMETHYLPYRIMIDINE AND SYNTHETIC INTERMEDIATE THEREOF | DPYD, TYMP, DTYMK | SMN1; SMN2 2788/4885LMNA 3856/4885MAPT 4817/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.