SCHEMBL8955160

SCHEMBL8955160

Cc1cc(CC(C)(C)C=O)cc(C)c1O

nearest known ligand 0.66

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 4/20 0.66
CYP3A4 P08684 3/20 0.66
CYP2D6 P10635 2/20 0.66
MEN1 O00255 2/20 0.66
ALDH1A1 P00352 2/20 0.66
TSHR P16473 2/20 0.66
MAPK1 P28482 2/20 0.66
BLM P54132 2/20 0.66
KMT2A Q03164 2/20 0.66
ATM Q13315 2/20 0.66
HIF1A Q16665 2/20 0.66
NPSR1 Q6W5P4 2/20 0.66
USP2 O75604 1/20 0.66
MAPT P10636 1/20 0.66
ESR1 P03372 1/20 0.39
ESR2 Q92731 1/20 0.39
CA1 P00915 1/20 0.38
CA2 P00918 1/20 0.38
PTGS1 P23219 6/20 0.38
PTGS2 P35354 6/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11347606 0.88 ALDH1A1 (0.81) CYP1A2CYP3A4CYP2D6MEN1ALDH1A1
SCHEMBL9748502 0.79 ALDH1A1 (0.58) CYP1A2CYP3A4CYP2D6MEN1ALDH1A1
SCHEMBL2372640 0.79 ALDH1A1 (1.00) CYP1A2CYP3A4CYP2D6MEN1ALDH1A1
SCHEMBL9248538 0.77 ESR1 (0.48) CYP1A2CYP3A4CYP2D6MEN1ALDH1A1
SCHEMBL29143186 0.77 ALDH1A1 (0.47) CYP1A2CYP3A4CYP2D6MEN1ALDH1A1
SCHEMBL30834937 0.77 ALDH1A1 (0.47) CYP1A2CYP3A4CYP2D6MEN1ALDH1A1
SCHEMBL11356556 0.77 MAPT (0.60) CYP1A2CYP3A4CYP2D6MEN1ALDH1A1
SCHEMBL8585296 0.75 SLC6A2 (0.46) CYP1A2CYP3A4CYP2D6MEN1ALDH1A1
SCHEMBL11288451 0.74 MEN1 (0.57) CYP1A2CYP3A4CYP2D6MEN1ALDH1A1
SCHEMBL4799617 0.73 CA1 (0.46) CYP1A2CYP3A4CYP2D6MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0568819-B1 Process for the preparation of 3-(hydroxyphenyl)-propionaldehydes and optionally the preparation of 3-(hydroxyphenyl)-propanols BASF AG (DE) 1996-01-03 EP disclosed
US-5304685-A Preparation of 3-(hydroxyphenyl)propionaldehydes and their hydrogenation to 3-(hydroxyphenyl)propanols BASF AKTIENGESELLSCHAFT (DE) 1994-04-19 US disclosed
EP-0568819-A1 Process for the preparation of 3-(hydroxyphenyl)-propionaldehydes and optionally the preparation of 3-(hydroxyphenyl)-propanols BASF Aktiengesellschaft (DE) 1993-11-10 EP disclosed
US-4243816-A PLASTIC STABILIZERS; DISCOLORATION INHIBITION CIBA-GEIGY CORPORATION (US) 1981-01-06 US disclosed
US-4134879-A AGING RESISTANCE, COLORFASTNESS CIBA-GEIGY CORPORATION (US) 1979-01-16 US disclosed