Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
| ▸ | DRD3 | P35462 | 1/20 | 0.47 |
| ▸ | FNTA | P49354 | 4/20 | 0.47 |
| ▸ | FNTB | P49356 | 4/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | TACR1 | P25103 | 2/20 | 0.43 |
| ▸ | TACR3 | P29371 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8783305 | 1.00 | DRD2 (0.47) | DRD2DRD3FNTAFNTBOPRK1 | |
| SCHEMBL8548651 | 1.00 | DRD2 (0.47) | DRD2DRD3FNTAFNTBOPRK1 | |
| SCHEMBL8893638 | 0.91 | DRD2 (0.46) | DRD2DRD3FNTAFNTBOPRK1 | |
| SCHEMBL8784611 | 0.91 | FNTA (0.46) | DRD2DRD3FNTAFNTBOPRK1 | |
| SCHEMBL8895210 | 0.91 | FNTA (0.44) | DRD2DRD3FNTAFNTBOPRK1 | |
| SCHEMBL8874906 | 0.89 | DRD2 (0.49) | DRD2DRD3FNTAFNTBOPRK1 | |
| SCHEMBL9142783 | 0.87 | FNTA (0.60) | FNTAFNTBKMT2ALMNAMEN1 | |
| SCHEMBL8956681 | 0.87 | TACR1 (0.58) | DRD2DRD3FNTAFNTBOPRK1 | |
| SCHEMBL8956847 | 0.87 | TACR1 (0.58) | DRD2DRD3FNTAFNTBOPRK1 | |
| SCHEMBL8783447 | 0.86 | FNTA (0.53) | FNTAFNTBKMT2AMEN1TACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5484804-A | Perhydroisoindole derivatives as antagonists of substance P | RHONE-POULENC RORER S.A. (FR) | 1996-01-16 | — | — | US | disclosed |
| US-5463077-A | Exhibit substance P antagonist activity | RHONE-POULENC RORER S.A. (FR) | 1995-10-31 | — | — | US | disclosed |