Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 2/20 | 0.49 |
| ▸ | RORC | P51449 | 11/20 | 0.46 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9244693 | 1.00 | TACR1 (0.49) | TACR1RORCUSP30TSHRALOX15 | |
| SCHEMBL8956761 | 0.89 | TACR1 (0.52) | TACR1RORCUSP30TSHRALOX15 | |
| SCHEMBL9266367 | 0.88 | RORC (0.46) | TACR1RORCUSP30TSHRALOX15 | |
| SCHEMBL8546697 | 0.87 | TACR1 (0.68) | TACR1RORCUSP30TSHR | |
| SCHEMBL7885109 | 0.87 | TACR1 (0.68) | TACR1RORCUSP30TSHR | |
| SCHEMBL9248237 | 0.87 | TACR1 (0.68) | TACR1RORCUSP30TSHR | |
| SCHEMBL9003029 | 0.81 | USP30 (0.45) | TACR1RORCUSP30TSHRALOX15 | |
| SCHEMBL9003033 | 0.81 | USP30 (0.45) | TACR1RORCUSP30TSHRALOX15 | |
| SCHEMBL9262375 | 0.81 | USP30 (0.45) | TACR1RORCUSP30TSHRALOX15 | |
| SCHEMBL9270074 | 0.81 | USP30 (0.45) | TACR1RORCUSP30TSHRALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5484804-A | Perhydroisoindole derivatives as antagonists of substance P | RHONE-POULENC RORER S.A. (FR) | 1996-01-16 | — | — | US | disclosed |
| US-5463077-A | Exhibit substance P antagonist activity | RHONE-POULENC RORER S.A. (FR) | 1995-10-31 | — | — | US | disclosed |