Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.77 |
| ▸ | MAPT | P10636 | 1/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.70 |
| ▸ | AKR1B1 | P15121 | 15/20 | 0.68 |
| ▸ | TSHR | P16473 | 1/20 | 0.63 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9216689 | 0.91 | KMT2A (0.72) | KMT2AMAPTALDH1A1AKR1B1 | |
| SCHEMBL9212517 | 0.87 | KMT2A (0.79) | KMT2AMAPTALDH1A1AKR1B1 | |
| SCHEMBL9327258 | 0.86 | MAPT (0.78) | KMT2AMAPTAKR1B1TSHR | |
| SCHEMBL11163802 | 0.84 | KMT2A (0.64) | KMT2AMAPTALDH1A1AKR1B1 | |
| SCHEMBL9209333 | 0.84 | KMT2A (0.58) | KMT2AMAPTALDH1A1AKR1B1TSHR | |
| SCHEMBL6890822 | 0.84 | MAPT (1.00) | KMT2AMAPTALDH1A1AKR1B1TSHR | |
| SCHEMBL10007138 | 0.81 | MAPT (0.79) | KMT2AMAPTALDH1A1AKR1B1PTGDR2 | |
| SCHEMBL9218891 | 0.81 | AKR1B1 (0.66) | KMT2AMAPTAKR1B1PTGDR2 | |
| SCHEMBL23966567 | 0.80 | MAPT (0.68) | KMT2AMAPTAKR1B1TSHRPTGDR2 | |
| SCHEMBL8128443 | 0.80 | MAPT (0.68) | KMT2AMAPTAKR1B1TSHRPTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5489592-A | ALDOSE REDUCTASE INHIBITORS FOR TREATMENT OF DIABETES-RELATED DISORDERS | LIPHA, LYONNAISE INDUSTRIELLE PHARMACEUTIQUE (FR) | 1996-02-06 | — | — | US | disclosed |
| US-4393062-A | ALDOSE REDUCTASE INHIBITOR | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1983-07-12 | — | — | US | disclosed |
| EP-0002895-B1 | ENZYME INHIBITORY PHTHALAZIN-4-YLACETIC ACID DERIVATIVES, PHARMACEUTICAL COMPOSITIONS THEREOF, AND PROCESS FOR THEIR MANUFACTURE | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1981-10-14 | — | — | EP | disclosed |
| US-4251528-A | ALDOSE REDUCTASE INHIBITORS USEFUL IN DIABETES, GALACTOSEMIA | IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) | 1981-02-17 | — | — | US | disclosed |
| EP-0002895-A1 | Enzyme inhibitory phthalazin-4-ylacetic acid derivatives, pharmaceutical compositions thereof, and process for their manufacture | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1979-07-11 | — | — | EP | disclosed |