SCHEMBL8957342

SCHEMBL8957342

O=[N+]([O-])OCCOc1ccccc1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KCNA3 P22001 1/20 0.52
CA12 O43570 3/20 0.51
CA1 P00915 3/20 0.51
CA2 P00918 3/20 0.51
CA4 P22748 3/20 0.51
CA9 Q16790 3/20 0.51
NPC1 O15118 3/20 0.49
RAB9A P51151 3/20 0.49
MAPT P10636 3/20 0.49
SMN1; SMN2 Q16637 2/20 0.49
DRD2 P14416 1/20 0.49
DRD4 P21917 1/20 0.49
DRD3 P35462 1/20 0.49
PKM P14618 2/20 0.48
ALDH1A1 P00352 3/20 0.47
RECQL P46063 2/20 0.47
TAAR1 Q96RJ0 1/20 0.47
PARP10 Q53GL7 1/20 0.46
KMT2A Q03164 2/20 0.45
MEN1 O00255 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8957335 0.81 SMN1; SMN2 (0.58) CA12CA1CA2CA4CA9
SCHEMBL2803032 0.81 CA12 (0.53) CA12CA1CA2CA4CA9
SCHEMBL2801843 0.81 CA12 (0.49) CA12CA1CA2CA4CA9
SCHEMBL8957416 0.81 CA12 (0.53) CA12CA1CA2CA4CA9
SCHEMBL8957299 0.81 MAPT (0.56) CA12CA1CA2CA4CA9
SCHEMBL8957481 0.80 PKM (0.64) CA12CA1CA2CA4CA9
SCHEMBL8957329 0.79 CHRNB2 (0.64) MAPTALDH1A1KMT2AMEN1
SCHEMBL11080434 0.79 CHRNB2 (0.51) MAPTDRD2DRD4DRD3ALDH1A1
SCHEMBL8957369 0.79 KMT2A (0.61) PKMKMT2A
SCHEMBL5286113 0.78 DRD2 (0.73) MAPTSMN1; SMN2DRD2DRD4DRD3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0689435-A1 USE OF SUBSTITUTED ALKYL NITRATES FOR THE TREATMENT OF PATHOLOGICALLY INCREASED INTRA-OCULAR PRESSURE BYK NEDERLAND BV (NL) 1996-01-03 EP claimed
WO-1994021248-A1 USE OF SUBSTITUTED ALKYL NITRATES FOR THE TREATMENT OF PATHOLOGICALLY INCREASED INTRA-OCULAR PRESSURE BYK NEDERLAND BV (NL) 1994-09-29 WO claimed
EP-0689435-A1 USE OF SUBSTITUTED ALKYL NITRATES FOR THE TREATMENT OF PATHOLOGICALLY INCREASED INTRA-OCULAR PRESSURE BYK NEDERLAND BV (NL) 1996-01-03 EP disclosed
WO-1994021248-A1 USE OF SUBSTITUTED ALKYL NITRATES FOR THE TREATMENT OF PATHOLOGICALLY INCREASED INTRA-OCULAR PRESSURE BYK NEDERLAND BV (NL) 1994-09-29 WO disclosed