SCHEMBL8957356

SCHEMBL8957356

NNC(=O)CCCCCCCCCCNC(=O)COc1ccc(CC(CN(CC(=O)O)CC(=O)O)N(CC(=O)O)CC(=O)O)cc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ITGB3 P05106 2/20 0.47
ITGA2B P08514 2/20 0.47
EPOR P19235 5/20 0.39
KDM4E B2RXH2 1/20 0.36
TSHR P16473 1/20 0.36
RECQL P46063 1/20 0.36
PTPN1 P18031 1/20 0.36
FOLH1 Q04609 1/20 0.35
HTT P42858 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
HDAC3 O15379 1/20 0.35
HDAC4 P56524 1/20 0.35
HDAC1 Q13547 1/20 0.35
HDAC7 Q8WUI4 1/20 0.35
HDAC2 Q92769 1/20 0.35
HDAC10 Q969S8 1/20 0.35
HDAC11 Q96DB2 1/20 0.35
HDAC8 Q9BY41 1/20 0.35
HDAC6 Q9UBN7 1/20 0.35
HDAC9 Q9UKV0 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8957358 0.95 ITGB3 (0.45) ITGB3ITGA2BEPORKDM4ETSHR
SCHEMBL8842421 0.87 ALDH1A1 (0.43) KDM4EHDAC8MEN1KMT2A
SCHEMBL8842428 0.82 ALDH1A1 (0.41) KDM4EHDAC8MEN1KMT2A
SCHEMBL8842690 0.81 ALDH1A1 (0.40) KDM4EHDAC8MEN1KMT2A
SCHEMBL8957276 0.80 ITGB3 (0.46) ITGB3ITGA2BEPORKDM4ETSHR
SCHEMBL8957385 0.80 ADRB1 (0.37) CYP1A2
SCHEMBL6140038 0.78 MAOB (0.44) TSHRSMN1; SMN2MEN1KMT2A
SCHEMBL6047708 0.78 EPOR (0.40) ITGB3ITGA2BEPORFOLH1MEN1
SCHEMBL6047694 0.78 EPOR (0.40) ITGB3ITGA2BEPORFOLH1MEN1
SCHEMBL8957288 0.77 ITGB3 (0.44) ITGB3ITGA2BEPORKDM4ETSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5482700-A Substituted polyamino, polycarboxy complexing agent dimers for MRI and X-ray contrast SCHERING AKTIENGESELLSCHAFT (DE) 1996-01-09 US disclosed
EP-0357622-A1 SUBSTITUTED COMPLEX-FORMING SUBSTANCES, COMPLEXES AND COMPLEX SALTS, PROCESS FOR MANUFACTURE THEREOF AND PHARMACEUTICAL AGENTS WHICH CONTAIN THEM SCHERING AKTIENGESELLSCHAFT (DE) 1990-03-14 EP disclosed
WO-1988007521-A1 SUBSTITUTED COMPLEX-FORMING SUBSTANCES, COMPLEXES AND COMPLEX SALTS, PROCESS FOR MANUFACTURE THEREOF AND PHARMACEUTICAL AGENTS WHICH CONTAIN THEM SCHERING AKTIENGESELLSCHAFT (DE) 1988-10-06 WO disclosed