Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.80 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.68 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.67 |
| ▸ | HTR1A | P08908 | 3/20 | 0.64 |
| ▸ | HTR7 | P34969 | 3/20 | 0.64 |
| ▸ | DRD2 | P14416 | 2/20 | 0.64 |
| ▸ | HTR2A | P28223 | 2/20 | 0.64 |
| ▸ | HTR6 | P50406 | 2/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL2213147 | 0.98 | KCNH2 (0.78) | KCNH2SIGMAR1CYP2D6HTR1AHTR7 | |
| SCHEMBL3187894 | 0.95 | KCNH2 (0.83) | KCNH2SIGMAR1HTR1AHTR7DRD2 | |
| SCHEMBL4255352 | 0.91 | KCNH2 (0.74) | KCNH2SIGMAR1HTR1AHTR7DRD2 | |
| SCHEMBL30767216 | 0.91 | KCNH2 (0.90) | KCNH2SIGMAR1HTR1AHTR7DRD2 | |
| Hydrochloric Acid SCHEMBL7658247 | 0.89 | KCNH2 (0.88) | KCNH2SIGMAR1HTR1AHTR7DRD2 | |
| SCHEMBL4525555 | 0.89 | KCNH2 (1.00) | KCNH2SIGMAR1HTR1AHTR7DRD2 | |
| SCHEMBL29739753 | 0.86 | KCNH2 (0.82) | KCNH2SIGMAR1HTR1AHTR7DRD2 | |
| SCHEMBL267526 | 0.86 | KCNH2 (0.82) | KCNH2SIGMAR1HTR1AHTR7DRD2 | |
| SCHEMBL2089938 | 0.85 | KCNH2 (0.80) | KCNH2SIGMAR1HTR1AHTR7DRD2 | |
| SCHEMBL8121567 | 0.85 | KCNH2 (0.85) | KCNH2SIGMAR1HTR1AHTR7DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8895558-B2 | Arylpiperazine-containing pyrrole 3-carboxamide derivatives for treating depressive disorders | GREEN CROSS CORPORATION (KR) | 2014-11-25 | — | — | US | disclosed |
| US-8895558-B2 | Arylpiperazine-containing pyrrole 3-carboxamide derivatives for treating depressive disorders | GREEN CROSS CORPORATION (KR) | 2014-11-25 | — | — | US | disclosed |
| US-20110178091-A1 | ARYLPIPERAZINE-CONTAINING PYRROLE 3-CARBOXAMIDE DERIVATIVES FOR TREATING DEPRESSIVE DISORDERS | GREEN CROSS CORPORATION (KR) | 2011-07-21 | — | — | US | disclosed |
| US-20110178091-A1 | ARYLPIPERAZINE-CONTAINING PYRROLE 3-CARBOXAMIDE DERIVATIVES FOR TREATING DEPRESSIVE DISORDERS | GREEN CROSS CORPORATION (KR) | 2011-07-21 | — | — | US | disclosed |
| WO-2010038948-A2 | ARYLPIPERAZINE-CONTAINING PYRROLE 3-CARBOXAMIDE DERIVATIVES FOR TREATING DEPRESSIVE DISORDERS | GREEN CROSS CORPORATION (KR) | 2010-04-08 | — | — | WO | disclosed |
| US-20100022509-A1 | Inhibitors of MshC and Homologs Thereof, and Methods of Identifying Same | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2010-01-28 | — | — | US | disclosed |
| US-20100022509-A1 | Inhibitors of MshC and Homologs Thereof, and Methods of Identifying Same | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2010-01-28 | — | — | US | disclosed |
| WO-2008036139-A2 | INHIBITORS OF MSHC AND HOMOLOGS THEREOF, AND METHODS OF IDENTIFYING SAME | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2008-03-27 | — | — | WO | disclosed |
| WO-2007117180-A1 | AZAHETEROCYCLES, COMBINATORY LIBRARY, FOCUSED LIBRARY, PHARMACEUTICAL COMPOSITION AND METHODS FOR THE PRODUCTION THEREOF | 'CHEMICAL DIVERSITY RESEARCH INSTITUTE' LTD. (RU) | 2007-10-18 | — | — | WO | disclosed |
| EP-0343961-B1 | Aryl- and heteroaryl piperazinyl carboxamides having central nervous system activity | AMERICAN HOME PROD (US) | 1996-01-10 | — | — | EP | disclosed |
| US-5482940-A | OBESITY, ALCOHOLISM | AMERICAN HOME PRODUCTS CORPORATION (US) | 1996-01-09 | — | — | US | disclosed |
| US-5380725-A | Antipsychotic agents and anxiolytic agents | AMERICAN HOME PRODUCTS CORPORATION (US) | 1995-01-10 | — | — | US | disclosed |
| US-5278160-A | Treating aggressive behavior | AMERICAN HOME PRODUCTS CORPORATION (US) | 1994-01-11 | — | — | US | disclosed |
| US-5254552-A | Cognition activators, psychological disorders | AMERICAN HOME PRODUCTS CORPORATION (US) | 1993-10-19 | — | — | US | disclosed |
| US-5164397-A | Hypotensive | SYNTHELABO (FR) | 1992-11-17 | — | — | US | disclosed |
| US-5106849-A | Treating anxiety, depression, psychoses | AMERICAN HOME PRODUCTS CORPORATION (US) | 1992-04-21 | — | — | US | disclosed |
| EP-0435749-A1 | Derivatives of 2-aminopyrimidine-4-carboxamide, their preparation and therapeutic use | SYNTHELABO (FR) | 1991-07-03 | — | — | EP | disclosed |
| US-5010078-A | Anxiolytic, antidepressant agents | AMERICAN HOME PRODUCTS CORPORATION (US) | 1991-04-23 | — | — | US | disclosed |
| US-4882432-A | ANTIDEPRESSANT, ANTIPSYCHOTIC | AMERICAN HOME PRODUCTS CORPORATION (US) | 1989-11-21 | — | — | US | disclosed |
| US-4585773-A | DIURETIC, HYPOTENSIVE | BRISTOL-MYERS COMPANY (US) | 1986-04-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110178091-A1 | ARYLPIPERAZINE-CONTAINING PYRROLE 3-CARBOXAMIDE DERIVATIVES FOR TREATING DEPRESSIVE DISORDERS | NPY5R, TPH2, MC5R | KCNH2 538/4885SIGMAR1 1205/4885CYP2D6 478/4885 |
| US-20100022509-A1 | Inhibitors of MshC and Homologs Thereof, and Methods of Identifying Same | ICMT, TST, OGA | KCNH2 4528/4885SIGMAR1 4874/4885CYP2D6 4058/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.