SCHEMBL267526

SCHEMBL267526

ClCCCN1CCN(c2cccc(Cl)c2)CC1

nearest known ligand 0.82

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
KCNH2 Q12809 2/20 0.82
SIGMAR1 Q99720 2/20 0.70
SLC6A2 P23975 1/20 0.64
SLC6A4 P31645 1/20 0.64
HTR1A P08908 3/20 0.62
HTR7 P34969 3/20 0.62
DRD2 P14416 2/20 0.62
HTR2A P28223 2/20 0.62
HTR6 P50406 2/20 0.62

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29739753 1.00 KCNH2 (0.82) KCNH2SIGMAR1SLC6A2SLC6A4HTR1A
Hydrochloric Acid SCHEMBL1254640 0.98 KCNH2 (0.80) KCNH2SIGMAR1SLC6A2SLC6A4HTR1A
SCHEMBL8121567 0.95 KCNH2 (0.85) KCNH2SIGMAR1SLC6A2SLC6A4HTR1A
SCHEMBL30767216 0.92 KCNH2 (0.90) KCNH2SIGMAR1SLC6A2SLC6A4HTR1A
Hydrochloric Acid SCHEMBL7658247 0.90 KCNH2 (0.88) KCNH2SIGMAR1SLC6A2SLC6A4HTR1A
SCHEMBL1254408 0.90 KCNH2 (0.77) KCNH2SIGMAR1HTR1AHTR7
SCHEMBL4525555 0.90 KCNH2 (1.00) KCNH2SIGMAR1HTR1AHTR7DRD2
Hydrochloric Acid SCHEMBL8950263 0.88 KCNH2 (0.65) KCNH2SIGMAR1SLC6A2SLC6A4HTR7
SCHEMBL16939690 0.86 KCNH2 (0.80) KCNH2SIGMAR1HTR1AHTR7DRD2
SCHEMBL8957648 0.86 KCNH2 (0.80) KCNH2SIGMAR1HTR1AHTR7DRD2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 339 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260108508-A1 TRAZODONE AND TRAZODONE HYDROCHLORIDE IN PURIFIED FORM AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A. (IT) 2026-04-23 US claimed
US-12221438-B2 Continuous process for the preparation of trazodone AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A. (IT) 2025-02-11 US claimed
US-20240139179-A1 TRAZODONE AND TRAZODONE HYDROCHLORIDE IN PURIFIED FORM AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A. (IT) 2024-05-02 US claimed
CN-111886235-B Continuous process for preparing trazodone 方济各安吉利克化学联合股份有限公司 2023-06-30 CN claimed
CN-111879767-B Color development test method of piperazine novel mental active substance 福建警察学院 2022-05-03 CN claimed
CN-111795963-B Method for chromogenic detection of piperazine novel psychotropic active substances 福建警察学院 2022-05-03 CN claimed
EP-3749668-B1 CONTINUOUS PROCESS FOR THE PREPARATION OF TRAZODONE ACRAF (IT) 2022-04-06 EP claimed
US-20210052577-A1 TRAZODONE AND TRAZODONE HYDROCHLORIDE IN PURIFIED FORM AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A. (IT) 2021-02-25 US claimed
CN-111879767-A Color development test method of piperazine novel mental active substance 福建警察学院 2020-11-03 CN claimed
CN-111795963-A Method for chromogenic detection of piperazine novel psychotropic active substances 福建警察学院 2020-10-20 CN claimed
US-20140296250-A1 TRAZODONE AND TRAZODONE HYDROCHLORIDE IN PURIFIED FORM AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A. (IT) 2014-10-02 US claimed
US-20140057922-A1 TRAZODONE AND TRAZODONE HYDROCHLORIDE IN PURIFIED FORM AZIENDE CHIM. RIUN. ANG. FRANC. A.C.R.A.F. S.P.A. (IT) 2014-02-27 US claimed
US-20130203771-A1 TRAZODONE AND TRAZODONE HYDROCHLORIDE IN PURIFIED FORM AZIENDE CHIM. RIUN. ANG. FRANC. A.C.R.A.F. S.P.A. (IT) 2013-08-08 US claimed
US-20130012520-A1 TRAZODONE AND TRAZODONE HYDROCHLORIDE IN PURIFIED FORM AZIENDE CHIM. RIUN. ANG. FRANC. A.C.R.A.F. S.P.A. (IT) 2013-01-10 US claimed
US-8314236-B2 Trazodone and trazodone hydrochloride in purified form AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A. (IT) 2012-11-20 US claimed
US-20120142699-A1 TRAZODONE AND TRAZODONE HYDROCHLORIDE IN PURIFIED FORM AZIENDE CHIM. RIUN. ANG. FRANC. A.C.R.A.F. S.P.A. (IT) 2012-06-07 US claimed
US-8133893-B2 Trazodone and trazodone hydrochloride in purified form AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A. (IT) 2012-03-13 US claimed
EP-2178850-A1 TRAZODONE AND TRAZODONE HYDROCHLORIDE IN PURIFIED FORM AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.p.A. (IT) 2010-04-28 EP claimed
US-20100056539-A1 TRAZODONE AND TRAZODONE HYDROCHLORIDE IN PURIFIED FORM AZIENDE CHIM. RIUM. ANG. FRANC. A.C.R.A.F.S.P.A. (IT) 2010-03-04 US claimed
WO-2009019133-A1 TRAZODONE AND TRAZODONE HYDROCHLORIDE IN PURIFIED FORM AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A. (IT) 2009-02-12 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100056539-A1 TRAZODONE AND TRAZODONE HYDROCHLORIDE IN PURIFIED FORM OPRD1, OPRM1, OPRK1 KCNH2 939/4885SIGMAR1 17/4885SLC6A2 980/4885
US-20210052577-A1 TRAZODONE AND TRAZODONE HYDROCHLORIDE IN PURIFIED FORM OPRD1, OPRK1, OPRM1 KCNH2 1564/4885SIGMAR1 34/4885SLC6A2 982/4885
US-12221438-B2 Continuous process for the preparation of trazodone CYP3A5, OPRK1, OPRD1 KCNH2 1256/4885SIGMAR1 63/4885SLC6A2 315/4885
US-20130012520-A1 TRAZODONE AND TRAZODONE HYDROCHLORIDE IN PURIFIED FORM OPRD1, POLL, OPRM1 KCNH2 791/4885SIGMAR1 16/4885SLC6A2 1200/4885
US-20140296250-A1 TRAZODONE AND TRAZODONE HYDROCHLORIDE IN PURIFIED FORM OPRD1, POLL, OPRM1 KCNH2 791/4885SIGMAR1 16/4885SLC6A2 1200/4885
US-20120142699-A1 TRAZODONE AND TRAZODONE HYDROCHLORIDE IN PURIFIED FORM OPRD1, POLL, OPRM1 KCNH2 791/4885SIGMAR1 16/4885SLC6A2 1200/4885
US-20130203771-A1 TRAZODONE AND TRAZODONE HYDROCHLORIDE IN PURIFIED FORM OPRD1, POLL, OPRM1 KCNH2 791/4885SIGMAR1 16/4885SLC6A2 1200/4885
US-20140057922-A1 TRAZODONE AND TRAZODONE HYDROCHLORIDE IN PURIFIED FORM OPRD1, OPRK1, OPRM1 KCNH2 1452/4885SIGMAR1 15/4885SLC6A2 1151/4885
US-20240139179-A1 TRAZODONE AND TRAZODONE HYDROCHLORIDE IN PURIFIED FORM OPRD1, POLL, OPRM1 KCNH2 791/4885SIGMAR1 16/4885SLC6A2 1200/4885
US-20260108508-A1 TRAZODONE AND TRAZODONE HYDROCHLORIDE IN PURIFIED FORM HTR1A, HTR3A, HTR2C KCNH2 1449/4885SIGMAR1 12/4885SLC6A2 405/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.