Sugi Predict

Sugi Predict / Compounds / SCHEMBL895773

SCHEMBL895773

SCHEMBL895773

CC(C)(C)OC(=O)C1CCCN1C(=O)OC(C)(C)C

nearest known ligand 0.61

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ HSD17B10 Q99714 2/20 0.61
▸ SMN1; SMN2 Q16637 1/20 0.53
▸ NPC1 O15118 1/20 0.53
▸ LMNA P02545 1/20 0.51
▸ NPSR1 Q6W5P4 1/20 0.51
▸ EPHX2 P34913 1/20 0.50
▸ UCHL1 P09936 2/20 0.49
▸ KLK7 P49862 1/20 0.48
▸ MEN1 O00255 3/20 0.47
▸ KMT2A Q03164 3/20 0.47
▸ ALDH1A1 P00352 2/20 0.47
▸ KDM4E B2RXH2 1/20 0.47
▸ GLA P06280 1/20 0.47
▸ GAA P10253 1/20 0.47
▸ HPGD P15428 1/20 0.47
▸ TSHR P16473 1/20 0.47
▸ POLB P06746 1/20 0.46
▸ SCN4A P35499 1/20 0.45
▸ USP30 Q70CQ3 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7286305 1.00 HSD17B10 (0.61) HSD17B10SMN1; SMN2NPC1LMNANPSR1
SCHEMBL19414808 1.00 HSD17B10 (0.61) HSD17B10SMN1; SMN2NPC1LMNANPSR1
SCHEMBL28153746 0.95 HSD17B10 (0.56) HSD17B10SMN1; SMN2NPC1LMNANPSR1
SCHEMBL927348 0.95 HSD17B10 (0.56) HSD17B10SMN1; SMN2NPC1LMNANPSR1
SCHEMBL23477366 0.92 HSD17B10 (0.59) HSD17B10SMN1; SMN2NPC1LMNANPSR1
SCHEMBL9544779 0.92 HSD17B10 (0.59) HSD17B10SMN1; SMN2NPC1LMNANPSR1
SCHEMBL6219879 0.92 HSD17B10 (0.59) HSD17B10SMN1; SMN2NPC1LMNANPSR1
SCHEMBL9727398 0.92 HSD17B10 (0.59) HSD17B10SMN1; SMN2NPC1LMNANPSR1
SCHEMBL28133679 0.91 HSD17B10 (0.62) HSD17B10SMN1; SMN2NPC1LMNANPSR1
SCHEMBL28925069 0.91 HSD17B10 (0.56) HSD17B10SMN1; SMN2NPC1LMNANPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116171280-A Casein kinase 1 delta modulators 詹森药业有限公司 2023-05-26 — — CN disclosed
CN-115702142-A Alkylaminoproline derivatives as alpha-2-delta-1 blockers 塔拉森斯调节公司 2023-02-14 — — CN disclosed
CN-104216224-B Photoresists comprising urethane components 罗门哈斯电子材料有限公司 2020-03-24 — — CN disclosed
EP-2560978-B1 INHIBITORS OF ARGINASE AND THEIR THERAPEUTIC APPLICATIONS MARS INC (US) 2019-01-30 — — EP disclosed
US-20180251479-A1 INHIBITORS OF ARGINASE AND THEIR THERAPEUTIC APPLICATIONS MARS, INCORPORATED 2018-09-06 — — US disclosed
US-9994594-B2 Inhibitors of arginase and their therapeutic applications MARS, INCORPORATED (US) 2018-06-12 — — US disclosed
US-20170183362-A1 INHIBITORS OF ARGINASE AND THEIR THERAPEUTIC APPLICATIONS MARS, INCORPORATED 2017-06-29 — — US disclosed
US-9040703-B2 Inhibitors of arginase and their therapeutic applications MARS, INCORPORATED (US) 2015-05-26 — — US disclosed
US-20140371175-A1 INHIBITORS OF ARGINASE AND THEIR THERAPEUTIC APPLICATIONS MARS, INCORPORATED 2014-12-18 — — US disclosed
US-20140356785-A1 PHOTORESISTS COMPRISING CARBAMATE COMPONENT U.S. BANK TRUST COMPANY, NATIONAL ASSOCIATION, AS NOTES COLLATERAL AGENT 2014-12-04 — — US disclosed
US-20140356785-A1 PHOTORESISTS COMPRISING CARBAMATE COMPONENT U.S. BANK TRUST COMPANY, NATIONAL ASSOCIATION, AS NOTES COLLATERAL AGENT 2014-12-04 — — US disclosed
US-20140356785-A1 PHOTORESISTS COMPRISING CARBAMATE COMPONENT U.S. BANK TRUST COMPANY, NATIONAL ASSOCIATION, AS NOTES COLLATERAL AGENT 2014-12-04 — — US disclosed
US-20140100217-A1 STRUCTURAL MIMETICS OF PROLINE-RICH PEPTIDES AND THEIR USE FORSCHUNGSVERBUND BERLIN E.V. (DE) 2014-04-10 — — US disclosed
US-20120083469-A1 INHIBITORS OF ARGINASE AND THEIR THERAPEUTIC APPLICATIONS MARS, INCORPORATED 2012-04-05 — — US disclosed
CN-102372764-A Novel peptides as NS3-serine protease inhibitors of hepatitis c virus SCHERING CORP 2012-03-14 — — CN disclosed
CN-102206247-A Novel peptides as NS3-serine protease inhibitors of hepatitis C virus DENDREON CORP 2011-10-05 — — CN disclosed
CN-1328278-C N-acylamino acid amide compounds and intermediates for preparation thereof UBE INDUSTRIES (JP) 2007-07-25 — — CN disclosed
CN-1498224-A Novel peptides as inhibitors of hepatitis C virus NS 3-serine protease ���鹫˾ 2004-05-19 — — CN disclosed
CN-1265661-A N-acylamino acid amide compounds and intermediates for preparation thereof UBE INDUSTRIES (JP) 2000-09-06 — — CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180251479-A1 INHIBITORS OF ARGINASE AND THEIR THERAPEUTIC APPLICATIONS ARG1, ARG2, PRMT9 HSD17B10 3334/4885SMN1; SMN2 3556/4885NPC1 2297/4885
US-20140100217-A1 STRUCTURAL MIMETICS OF PROLINE-RICH PEPTIDES AND THEIR USE NPY1R, NPR1, NPY2R HSD17B10 2437/4885SMN1; SMN2 114/4885NPC1 2006/4885
US-20170183362-A1 INHIBITORS OF ARGINASE AND THEIR THERAPEUTIC APPLICATIONS ARG1, ARG2, PRMT9 HSD17B10 3334/4885SMN1; SMN2 3556/4885NPC1 2297/4885
US-20120083469-A1 INHIBITORS OF ARGINASE AND THEIR THERAPEUTIC APPLICATIONS ARG1, ARG2, PRMT9 HSD17B10 3334/4885SMN1; SMN2 3556/4885NPC1 2297/4885
US-20140371175-A1 INHIBITORS OF ARGINASE AND THEIR THERAPEUTIC APPLICATIONS ARG1, ARG2, PRMT9 HSD17B10 3334/4885SMN1; SMN2 3556/4885NPC1 2297/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.