Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | MLYCD | O95822 | 1/20 | 0.38 |
| ▸ | IMPDH2 | P12268 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | THRA | P10827 | 2/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | SENP1 | Q9P0U3 | 2/20 | 0.37 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8957970 | 0.84 | CA12 (0.41) | — | |
| SCHEMBL8957976 | 0.83 | LMNA (0.48) | NPC1RAB9ASMN1; SMN2KDM4EMEN1 | |
| SCHEMBL8958053 | 0.80 | CA12 (0.40) | SMN1; SMN2KDM4EATMMEN1KMT2A | |
| SCHEMBL8467038 | 0.79 | ALDH1A1 (0.52) | SMN1; SMN2MEN1KMT2AAKR1B1 | |
| SCHEMBL7223994 | 0.79 | POLB (0.36) | RAB9AKDM4EMEN1KMT2AAKR1B1 | |
| SCHEMBL7228473 | 0.79 | MAPT (0.40) | NPC1RAB9ASMN1; SMN2MEN1KMT2A | |
| SCHEMBL8958001 | 0.78 | CA12 (0.40) | NPC1RAB9AMEN1KMT2ATHRB | |
| SCHEMBL8957820 | 0.78 | THRA (0.38) | NPC1RAB9ASMN1; SMN2MEN1KMT2A | |
| SCHEMBL7223364 | 0.78 | POLB (0.45) | NPC1RAB9AMEN1KMT2AAKR1B1 | |
| SCHEMBL7225299 | 0.78 | ALDH1A1 (0.43) | SMN1; SMN2KDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0469889-B1 | (p-Carbonylaminophenyl)-sulphonyl-nitromethane derivatives | ZENECA LTD (GB) | 1996-01-17 | — | — | EP | disclosed |
| US-5189031-A | Inhibitor of enzyme aldose reductase, useful in the treatment of certain peripheral effects of diabetes and galactosemia | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-02-23 | — | — | US | disclosed |
| US-5110808-A | Aldose reductase inhibitors; peripheral effects of diabetes and galactosemia | IMPERIAL CHEMICAL INDUSTRIES, PLC (GB) | 1992-05-05 | — | — | US | disclosed |
| EP-0469889-A1 | (p-Carbonylaminophenyl)-sulphonyl-nitromethane derivatives | ZENECA LIMITED (GB) | 1992-02-05 | — | — | EP | disclosed |