Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 3/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.32 |
| ▸ | MAPT | P10636 | 4/20 | 0.32 |
| ▸ | ACP1 | P24666 | 1/20 | 0.32 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.31 |
| ▸ | IDH1 | O75874 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8958011 | 0.89 | POLB (0.33) | RAB9AMEN1KMT2AAKR1B1POLB | |
| SCHEMBL7223994 | 0.88 | POLB (0.36) | RAB9AMEN1KMT2AAKR1B1POLB | |
| SCHEMBL7228473 | 0.88 | MAPT (0.40) | RAB9AMEN1KMT2APOLBALDH1A1 | |
| SCHEMBL7225299 | 0.87 | ALDH1A1 (0.43) | MEN1KMT2APOLBGAAALDH1A1 | |
| SCHEMBL7223364 | 0.87 | POLB (0.45) | RAB9AMEN1KMT2AAKR1B1POLB | |
| SCHEMBL7230766 | 0.86 | POLB (0.42) | MEN1KMT2AAKR1B1POLBGAA | |
| SCHEMBL8957820 | 0.84 | THRA (0.38) | RAB9AMEN1KMT2AAKR1B1GAA | |
| SCHEMBL8957970 | 0.83 | CA12 (0.41) | GAAALDH1A1 | |
| SCHEMBL7225323 | 0.83 | HDAC3 (0.42) | MEN1KMT2APOLBGAAALDH1A1 | |
| SCHEMBL8957815 | 0.83 | ALDH1A1 (0.33) | RAB9AMEN1KMT2AAKR1B1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0469889-B1 | (p-Carbonylaminophenyl)-sulphonyl-nitromethane derivatives | ZENECA LTD (GB) | 1996-01-17 | — | — | EP | disclosed |
| US-5189031-A | Inhibitor of enzyme aldose reductase, useful in the treatment of certain peripheral effects of diabetes and galactosemia | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-02-23 | — | — | US | disclosed |
| US-5110808-A | Aldose reductase inhibitors; peripheral effects of diabetes and galactosemia | IMPERIAL CHEMICAL INDUSTRIES, PLC (GB) | 1992-05-05 | — | — | US | disclosed |
| EP-0469889-A1 | (p-Carbonylaminophenyl)-sulphonyl-nitromethane derivatives | ZENECA LIMITED (GB) | 1992-02-05 | — | — | EP | disclosed |