Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.70 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.63 |
| ▸ | HPGD | P15428 | 3/20 | 0.63 |
| ▸ | RAB9A | P51151 | 3/20 | 0.63 |
| ▸ | LMNA | P02545 | 3/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.63 |
| ▸ | NPC1 | O15118 | 2/20 | 0.63 |
| ▸ | MEN1 | O00255 | 2/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.63 |
| ▸ | GLA | P06280 | 1/20 | 0.63 |
| ▸ | GAA | P10253 | 1/20 | 0.63 |
| ▸ | MAPT | P10636 | 1/20 | 0.63 |
| ▸ | ATM | Q13315 | 1/20 | 0.63 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.61 |
| ▸ | MMP13 | P45452 | 8/20 | 0.59 |
| ▸ | MMP2 | P08253 | 6/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL656018 | 0.88 | KDM4E (0.74) | ALOX15KDM4EALDH1A1HPGDRAB9A | |
| Hydrochloric Acid SCHEMBL28674698 | 0.87 | KDM4E (0.72) | ALOX15KDM4EALDH1A1HPGDRAB9A | |
| SCHEMBL5623372 | 0.85 | KDM4E (0.78) | ALOX15KDM4EALDH1A1HPGDRAB9A | |
| SCHEMBL17368519 | 0.84 | ALOX15 (0.72) | ALOX15KDM4EALDH1A1HPGDRAB9A | |
| SCHEMBL71101 | 0.84 | ALOX15 (0.72) | ALOX15KDM4EALDH1A1HPGDRAB9A | |
| SCHEMBL4907791 | 0.84 | ALOX15 (0.72) | ALOX15KDM4EALDH1A1HPGDRAB9A | |
| SCHEMBL654862 | 0.83 | HRH4 (0.55) | ALOX15KDM4EALDH1A1HPGDRAB9A | |
| SCHEMBL17092514 | 0.83 | HRH4 (0.55) | ALOX15KDM4EALDH1A1HPGDRAB9A | |
| SCHEMBL327597 | 0.83 | MMP13 (0.80) | ALOX15KDM4EALDH1A1HPGDRAB9A | |
| SCHEMBL5917481 | 0.82 | ALOX15 (0.70) | ALOX15KDM4EALDH1A1HPGDRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0424261-B1 | Dyeing composition containing oxidation dyes precursors and aminoindole derivatives as coupling agent | OREAL (FR) | 1996-01-03 | — | — | EP | claimed |
| EP-0425345-B1 | Keratinic fibres dyeing process with amino-indoles, composition and use devices | OREAL (FR) | 1994-09-14 | — | — | EP | claimed |
| EP-0460996-B1 | Keratinic fibres dyeing process with an aminoindol associated with a quinone derivative | OREAL (FR) | 1994-09-14 | — | — | EP | claimed |
| US-5254135-A | Applying indole dye, developing with oxidizing system | L'OREAL (FR) | 1993-10-19 | — | — | US | claimed |
| US-5180400-A | METHOD FOR DYEING KERATINOUS FIBRES USING AN AMINOINDOLE IN COMBINATION WITH A QUINONE DERIVATIVE | L'OREAL (FR) | 1993-01-19 | — | — | US | claimed |
| EP-0460996-A1 | Keratinic fibres dyeing process with an aminoindol associated with a quinone derivative | L'OREAL (FR) | 1991-12-11 | — | — | EP | claimed |
| EP-0425345-A1 | Keratinic fibres dyeing process with amino-indoles, composition and use devices | L'OREAL (FR) | 1991-05-02 | — | — | EP | claimed |
| EP-0424261-A1 | Dyeing composition containing oxidation dyes precursors and aminoindole derivatives as coupling agent | L'OREAL (FR) | 1991-04-24 | — | — | EP | claimed |
| EP-3882245-A1 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | Vertex Pharmaceuticals Incorporated (US) | 2021-09-22 | — | — | EP | disclosed |
| CN-111808079-A | Indole ASK1 small molecule inhibitor and preparation method and application thereof | 中国药科大学 | 2020-10-23 | — | — | CN | disclosed |
| CN-108191858-B | A kind of intermediate preparing pyrroloquinoline quinone and preparation method | 山东康迈祺生物科技有限公司 | 2019-11-26 | — | — | CN | disclosed |
| US-10183932-B2 | Substituted oxopyridine derivatives and use thereof cardiovascular disorders | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2019-01-22 | — | — | US | disclosed |
| CN-108191858-A | A kind of intermediate and preparation method for preparing pyrroloquinoline quinone | 山东康迈祺生物科技有限公司 | 2018-06-22 | — | — | CN | disclosed |
| CN-107089982-B | 4, 5-disubstituted-1-hydrogen-pyrrole (2, 3-f) quinoline-2, 7, 9-tricarboxylate compound and application thereof | 王靖林 | 2018-06-05 | — | — | CN | disclosed |
| EP-0602851-A1 | Quinazoline derivatives | ZENECA LIMITED (GB) | 1994-06-22 | — | — | EP | disclosed |
| US-5254135-A | Applying indole dye, developing with oxidizing system | L'OREAL (FR) | 1993-10-19 | — | — | US | disclosed |
| US-5180400-A | METHOD FOR DYEING KERATINOUS FIBRES USING AN AMINOINDOLE IN COMBINATION WITH A QUINONE DERIVATIVE | L'OREAL (FR) | 1993-01-19 | — | — | US | disclosed |
| EP-0460996-A1 | Keratinic fibres dyeing process with an aminoindol associated with a quinone derivative | L'OREAL (FR) | 1991-12-11 | — | — | EP | disclosed |
| EP-0425345-A1 | Keratinic fibres dyeing process with amino-indoles, composition and use devices | L'OREAL (FR) | 1991-05-02 | — | — | EP | disclosed |
| EP-0424261-A1 | Dyeing composition containing oxidation dyes precursors and aminoindole derivatives as coupling agent | L'OREAL (FR) | 1991-04-24 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10183932-B2 | Substituted oxopyridine derivatives and use thereof cardiovascular disorders | OGFOD1, VASP, PNPO | ALOX15 608/4885KDM4E 1342/4885ALDH1A1 1195/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.