SCHEMBL656018

SCHEMBL656018

CCOC(=O)c1cc2cc(N)ccc2[nH]1

nearest known ligand 0.74

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 3/20 0.74
ALDH1A1 P00352 3/20 0.74
HPGD P15428 3/20 0.74
RAB9A P51151 3/20 0.74
SMN1; SMN2 Q16637 2/20 0.74
HSD17B10 Q99714 1/20 0.74
MMP13 P45452 8/20 0.71
MMP2 P08253 6/20 0.71
LMNA P02545 3/20 0.68
NPC1 O15118 2/20 0.68
HTT P42858 1/20 0.68
L3MBTL1 Q9Y468 1/20 0.68
HRH3 Q9Y5N1 1/20 0.68
MEN1 O00255 2/20 0.63
KMT2A Q03164 2/20 0.63
GLA P06280 1/20 0.63
GAA P10253 1/20 0.63
MAPT P10636 1/20 0.63
ATM Q13315 1/20 0.63
MMP14 P50281 4/20 0.62

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL28674698 0.99 KDM4E (0.72) KDM4EALDH1A1HPGDRAB9ASMN1; SMN2
SCHEMBL8959155 0.88 ALOX15 (0.70) KDM4EALDH1A1HPGDRAB9ASMN1; SMN2
SCHEMBL30994860 0.85 RAB9A (1.00) KDM4EALDH1A1HPGDRAB9ASMN1; SMN2
SCHEMBL85706 0.85 RAB9A (1.00) KDM4EALDH1A1HPGDRAB9ASMN1; SMN2
SCHEMBL829242 0.84 KDM4E (0.76) KDM4EALDH1A1HPGDRAB9ASMN1; SMN2
SCHEMBL68923 0.84 HRH3 (0.84) KDM4EALDH1A1HPGDRAB9ASMN1; SMN2
SCHEMBL829213 0.84 KDM4E (0.76) KDM4EALDH1A1HPGDRAB9ASMN1; SMN2
SCHEMBL10395119 0.83 KDM4E (0.67) KDM4EALDH1A1HPGDRAB9ASMN1; SMN2
SCHEMBL617200 0.83 XDH (0.59) KDM4EALDH1A1HPGDRAB9ASMN1; SMN2
SCHEMBL6517054 0.83 MMP13 (1.00) KDM4EALDH1A1HPGDRAB9ASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 524 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114605303-A Synthesis method of delavirdine and intermediate thereof 武汉工程大学 2022-06-10 CN claimed
CN-107739368-B N-substituted-5- ((4-substituted pyrimidine-2-yl) amino) indole derivatives, and preparation method and application thereof 厦门大学 2020-02-14 CN claimed
CN-104829597-B 1H- indoles -2- carbohydrazide derivatives and its preparation method and application 厦门大学 2018-07-17 CN claimed
EP-2948454-B1 TRIAZINE COMPOUNDS AND A PROCESS FOR PREPARATION THEREOF COUNCIL OF SCIENT & IND RES AN INDIAN REGISTERED BODY INCORPORATED UNDER THE REGISTRATION OF SOCIETI (IN) 2017-05-31 EP claimed
US-9447105-B2 Triazine compounds and a process for preparation thereof COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) 2016-09-20 US claimed
US-20150353566-A1 TRIAZINE COMPOUNDS AND A PROCESS FOR PREPARATION THEREOF COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) 2015-12-10 US claimed
EP-2948454-A1 TRIAZINE COMPOUNDS AND A PROCESS FOR PREPARATION THEREOF Council of Scientific & Industrial Research An Indian registered body incorporated under the Registration of Societies Act (Act XXI of 1860) (IN) 2015-12-02 EP claimed
WO-2014115171-A1 TRIAZINE COMPOUNDS AND A PROCESS FOR PREPARATION THEREOF COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) 2014-07-31 WO claimed
US-12465588-B2 Indole carboxamide derivative and pharmaceutical composition containing same KUKJE PHARMA CO., LTD. (KR) 2025-11-11 US disclosed
EP-4568971-A1 ANTAGONISTS OF 5-HYDROXYTRYPTAMINE RECEPTOR SUBTYPE 2B Vanderbilt University (US) 2025-06-18 EP disclosed
US-RE50453-E1 Indole derivatives as CFTR modulators VERTEX PHARMACEUTICALS INCORPORATED (US) 2025-06-10 US disclosed
CN-120082310-A Adhesive for OLED protective film and preparation method thereof 江苏欧跃环保科技有限公司 2025-06-03 CN disclosed
CN-113439084-B Sesqui-carcinomycin analogue 奥克兰联合服务有限公司 2025-02-25 CN disclosed
CN-114302874-B Indole carboxamide derivatives and pharmaceutical compositions containing the same 国际药品株式会社 2025-02-25 CN disclosed
US-4978757-A BACTERICIDES, ANTITUMOR AGENTS, UV RAD ABSORBERS THE UPJOHN COMPANY (US) 1990-12-18 US disclosed
US-4912227-A 1,2,8,8A-tetrahydrocyclopropa(c)pyrrolo(3,2-e)-indol-4-(5H)-ones and related compounds THE UPJOHN COMPANY (US) 1990-03-27 US disclosed
WO-1990002746-A1 NOVEL CC-1065 ANALOGS HAVING TWO CPI SUBUNITS THE UPJOHN COMPANY (US) 1990-03-22 WO disclosed
EP-0359454-A1 Novel CC-1065 analogs having two CPI subunits THE UPJOHN COMPANY (US) 1990-03-21 EP disclosed
EP-0088350-B1 CARBOXYALKYL DIPEPTIDES, PROCESSES FOR THEIR PRODUCTION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM SCHERING CORPORATION (US) 1985-02-20 EP disclosed
EP-0088350-A1 Carboxyalkyl dipeptides, processes for their production and pharmaceutical compositions containing them SCHERING CORPORATION (US) 1983-09-14 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12465588-B2 Indole carboxamide derivative and pharmaceutical composition containing same PTGES, PTGES2, PTGS1 KDM4E 2460/4885ALDH1A1 331/4885HPGD 10/4885
US-20150353566-A1 TRIAZINE COMPOUNDS AND A PROCESS FOR PREPARATION THEREOF TPH2, IDO2, INMT KDM4E 862/4885ALDH1A1 2885/4885HPGD 2149/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.