Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 3/20 | 0.45 |
| ▸ | HTR2A | P28223 | 2/20 | 0.45 |
| ▸ | FABP4 | P15090 | 2/20 | 0.39 |
| ▸ | CDK4 | P11802 | 1/20 | 0.36 |
| ▸ | CCND1 | P24385 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | TFPI2 | P48307 | 1/20 | 0.34 |
| ▸ | PPARD | Q03181 | 1/20 | 0.33 |
| ▸ | PPARA | Q07869 | 1/20 | 0.33 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.33 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.33 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27342171 | 1.00 | HTR2C (0.45) | HTR2CHTR2AFABP4CDK4CCND1 | |
| SCHEMBL27528051 | 0.90 | HTR2A (0.45) | HTR2CHTR2AFABP4PRMT5MAOA | |
| SCHEMBL8959581 | 0.90 | HTR2A (0.45) | HTR2CHTR2AFABP4PRMT5MAOA | |
| SCHEMBL27340857 | 0.87 | HTR2A (0.46) | HTR2CHTR2AFABP4HDAC3HDAC1 | |
| SCHEMBL8959588 | 0.87 | HTR2A (0.46) | HTR2CHTR2ACDK4CCND1HDAC3 | |
| SCHEMBL27524962 | 0.87 | HTR2A (0.46) | HTR2CHTR2ACDK4CCND1HDAC3 | |
| SCHEMBL8959479 | 0.87 | HTR2C (0.46) | HTR2CHTR2AFABP4CDK4CCND1 | |
| SCHEMBL8959678 | 0.87 | HTR2C (0.46) | HTR2CHTR2AFABP4CDK4CCND1 | |
| SCHEMBL8959618 | 0.87 | HTR2A (0.46) | HTR2CHTR2AFABP4HDAC3HDAC1 | |
| SCHEMBL8959608 | 0.83 | HTR2A (0.45) | HTR2CHTR2AHDAC1HDAC6MTNR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5494928-A | FOR CENTRAL NERVOUS SYSTEM DISORDERS, BLOCKING SEROTONIN RECEPTORS, ANTIDEPRESSANTS | HOFFMANN-LA ROCHE INC. (US) | 1996-02-27 | — | — | US | disclosed |