Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C known ✓ | P28335 | 8/20 | 0.46 |
| ▸ | HTR2A known ✓ | P28223 | 7/20 | 0.46 |
| ▸ | ICMT | O60725 | 3/20 | 0.41 |
| ▸ | HTR3A | P46098 | 4/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | AR | P10275 | 1/20 | 0.38 |
| ▸ | TDO2 | P48775 | 1/20 | 0.37 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL27342770 | 1.00 | HTR2C (0.46) | HTR2CHTR2AICMTHTR3ALMNA | |
| Fumaric Acid SCHEMBL8959743 | 1.00 | HTR2C (0.46) | HTR2CHTR2AICMTHTR3ALMNA | |
| SCHEMBL9228920 | 0.89 | HTR2C (0.56) | HTR2CHTR2A | |
| Fumaric Acid SCHEMBL27342763 | 0.87 | ICMT (0.48) | HTR2CHTR2AICMTHTR3ALMNA | |
| Fumaric Acid SCHEMBL8959943 | 0.81 | HTR2A (0.47) | HTR2CHTR2AICMTLMNAPMP22 | |
| Fumaric Acid SCHEMBL8959951 | 0.81 | HTR2A (0.47) | HTR2CHTR2AICMTLMNAPMP22 | |
| Fumaric Acid SCHEMBL27339949 | 0.81 | HTR2A (0.47) | HTR2CHTR2AICMTLMNAPMP22 | |
| Fumaric Acid SCHEMBL27524957 | 0.81 | AR (0.48) | ICMTHTR3AARPTGDR2 | |
| Fumaric Acid SCHEMBL8959669 | 0.78 | HTR2C (0.78) | HTR2CHTR2A | |
| Fumaric Acid SCHEMBL8959477 | 0.78 | HTR2C (0.78) | HTR2CHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5494928-A | FOR CENTRAL NERVOUS SYSTEM DISORDERS, BLOCKING SEROTONIN RECEPTORS, ANTIDEPRESSANTS | HOFFMANN-LA ROCHE INC. (US) | 1996-02-27 | — | — | US | disclosed |