Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 known ✓ | Q01959 | 2/20 | 0.37 |
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.32 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 4/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.37 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.37 |
| ▸ | HRH1 | P35367 | 2/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
| ▸ | PDE6A | P16499 | 1/20 | 0.37 |
| ▸ | MC4R | P32245 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8959972 | 0.79 | CHKA (0.54) | LMNASMN1; SMN2CHKAALDH1A1HTT | |
| SCHEMBL13197528 | 0.78 | CHKA (0.56) | LMNASMN1; SMN2CHKAALDH1A1HTT | |
| SCHEMBL21858232 | 0.75 | ACHE (0.48) | TSHRLMNAADRA2AADRA2CADRA1A | |
| SCHEMBL13197531 | 0.73 | CHRNA7 (0.35) | CYP2C19LMNACYP2D6CYP1A2KMT2A | |
| SCHEMBL4424544 | 0.73 | TSHR (0.39) | TSHRLMNATAAR1ADRA2AADRA1A | |
| SCHEMBL24727378 | 0.72 | BCHE (0.43) | TSHRADRA2AADRA1ASLC6A3KCNH2 | |
| SCHEMBL2207843 | 0.72 | TSHR (0.43) | TSHRLMNATAAR1KMT2ASMN1; SMN2 | |
| SCHEMBL4425512 | 0.72 | BCHE (0.45) | TSHRADRA2AADRA1ASLC6A3KCNH2 | |
| SCHEMBL21049526 | 0.71 | SIGMAR1 (0.53) | TSHRLMNAOPRM1KMT2AOPRK1 | |
| Hydrochloric Acid SCHEMBL9673984 | 0.70 | CHRM2 (0.47) | CYP2C19LMNACYP2D6CYP1A2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0483480-B1 | Process for the preparation of organosilanes containing a methacryloxy group or an acryloxy group | HUELS CHEMISCHE WERKE AG (DE) | 1996-01-31 | — | — | EP | disclosed |
| US-5117027-A | Esterification | HULS AKTIENGESELLSCHAFT (DE) | 1992-05-26 | — | — | US | disclosed |
| EP-0483480-A1 | Process for the preparation of organosilanes containing a methacryloxy group or an acryloxy group | HÜLS AKTIENGESELLSCHAFT (DE) | 1992-05-06 | — | — | EP | disclosed |