Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHKA | P35790 | 9/20 | 0.54 |
| ▸ | KDM4A | O75164 | 2/20 | 0.42 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 4/20 | 0.39 |
| ▸ | HTT | P42858 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13197528 | 0.98 | CHKA (0.56) | CHKAKDM4AKDM2ALMNAHTT | |
| Hydrochloric Acid SCHEMBL8959775 | 0.84 | CHKA (0.58) | CHKAKDM4AKDM2ALMNAHTT | |
| Hydrochloric Acid SCHEMBL8959754 | 0.79 | TSHR (0.42) | CHKALMNAHTTSMN1; SMN2ALDH1A1 | |
| SCHEMBL13197531 | 0.78 | CHRNA7 (0.35) | LMNAHTTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL21858232 | 0.76 | ACHE (0.48) | LMNAHTTSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL6115253 | 0.76 | CHKA (0.70) | CHKAKDM4AKDM2ALMNAHTT | |
| SCHEMBL2859572 | 0.74 | CHKA (0.73) | CHKAKDM4AKDM2ALMNAHTT | |
| Hydrochloric Acid SCHEMBL9328425 | 0.73 | CHKA (0.78) | CHKAKDM4AKDM2ALMNAHTT | |
| Hydrochloric Acid SCHEMBL6115401 | 0.73 | CHKA (0.78) | CHKAKDM4AKDM2ALMNAHTT | |
| Hydrochloric Acid SCHEMBL9618165 | 0.72 | CHKA (0.42) | CHKALMNAHTTSMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0483480-B1 | Process for the preparation of organosilanes containing a methacryloxy group or an acryloxy group | HUELS CHEMISCHE WERKE AG (DE) | 1996-01-31 | — | — | EP | disclosed |
| US-5117027-A | Esterification | HULS AKTIENGESELLSCHAFT (DE) | 1992-05-26 | — | — | US | disclosed |
| EP-0483480-A1 | Process for the preparation of organosilanes containing a methacryloxy group or an acryloxy group | HÜLS AKTIENGESELLSCHAFT (DE) | 1992-05-06 | — | — | EP | disclosed |