Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.55 |
| ▸ | HTR2A | P28223 | 6/20 | 0.49 |
| ▸ | HTR2B | P41595 | 2/20 | 0.46 |
| ▸ | HTR6 | P50406 | 1/20 | 0.46 |
| ▸ | HTR2C | P28335 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
| ▸ | HTR5A | P47898 | 1/20 | 0.41 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 2/20 | 0.39 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL788913 | 0.85 | HTR2A (0.57) | GPR84HTR2AHTR2BHTR6HTR2C | |
| SCHEMBL28167758 | 0.84 | HTR2A (0.60) | HTR2AHTR2BHTR6HTR2CHTR1A | |
| SCHEMBL31744662 | 0.81 | GPR84 (0.44) | GPR84HTR2AHTR6KDM4EMAPT | |
| SCHEMBL28167759 | 0.79 | FFAR1 (0.53) | GPR84HTR2AHTR2BHTR6HTR2C | |
| SCHEMBL28337297 | 0.79 | NR4A2 (0.55) | GPR84HTR2AHTR2BHTR6HTR2C | |
| SCHEMBL30089577 | 0.79 | HTR2A (0.50) | HTR2AHTR2BHTR6HTR2CHTR1A | |
| SCHEMBL27920584 | 0.78 | SLC22A6 (0.59) | GPR84HTR2AMTNR1AMTNR1BNR4A2 | |
| SCHEMBL1224614 | 0.77 | GPR84 (0.64) | GPR84HTR2AHTR2BHTR2CATM | |
| SCHEMBL30552280 | 0.77 | GPR84 (0.64) | GPR84HTR2AHTR2BHTR2CATM | |
| SCHEMBL27772015 | 0.74 | GPR84 (0.44) | GPR84HTR2AMTNR1AMTNR1BNR4A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5494928-A | FOR CENTRAL NERVOUS SYSTEM DISORDERS, BLOCKING SEROTONIN RECEPTORS, ANTIDEPRESSANTS | HOFFMANN-LA ROCHE INC. (US) | 1996-02-27 | — | — | US | disclosed |
| EP-0655440-A2 | 1-Aminoethylindoles | F. HOFFMANN-LA ROCHE AG (CH) | 1995-05-31 | — | — | EP | disclosed |