Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM5 | Q9NZQ8 | 13/20 | 0.44 |
| ▸ | KDR | P35968 | 2/20 | 0.40 |
| ▸ | GSK3B | P49841 | 2/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.38 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL8959767 | 0.89 | TRPM5 (0.47) | TRPM5KDRGSK3BFLT3 | |
| Fumaric Acid SCHEMBL8959756 | 0.89 | TRPM5 (0.47) | TRPM5KDRGSK3BFLT3 | |
| SCHEMBL9231573 | 0.79 | HTR2C (0.55) | HTR2C | |
| SCHEMBL9229358 | 0.77 | HTR2C (0.39) | TRPM5HTR2C | |
| SCHEMBL9229362 | 0.77 | HTR2C (0.39) | TRPM5HTR2C | |
| SCHEMBL8959806 | 0.74 | HTR2A (0.40) | TRPM5KDRGSK3BFLT3HTR2C | |
| SCHEMBL8959761 | 0.71 | TRPM5 (0.39) | TRPM5HTR2C | |
| Fumaric Acid SCHEMBL8959671 | 0.71 | HTR2C (0.45) | TRPM5HTR2C | |
| Fumaric Acid SCHEMBL8959661 | 0.71 | HTR2C (0.45) | TRPM5HTR2C | |
| SCHEMBL8959667 | 0.70 | TRPM5 (0.38) | TRPM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0655440-A2 | 1-Aminoethylindoles | F. HOFFMANN-LA ROCHE AG (CH) | 1995-05-31 | — | — | EP | claimed |
| US-5494928-A | FOR CENTRAL NERVOUS SYSTEM DISORDERS, BLOCKING SEROTONIN RECEPTORS, ANTIDEPRESSANTS | HOFFMANN-LA ROCHE INC. (US) | 1996-02-27 | — | — | US | disclosed |
| EP-0655440-A2 | 1-Aminoethylindoles | F. HOFFMANN-LA ROCHE AG (CH) | 1995-05-31 | — | — | EP | disclosed |